287808

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4292460..4293033 Replicon chromosome
Accession NZ_LR134355
Organism Mycolicibacterium chitae strain NCTC10485

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL338_RS20640 Protein ID WP_126335451.1
Coordinates 4292683..4293033 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EL338_RS20635 Protein ID WP_126335450.1
Coordinates 4292460..4292696 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL338_RS20615 4289173..4289490 + 318 WP_126335447.1 WhiB family transcriptional regulator -
EL338_RS20620 4289519..4290025 + 507 WP_126335448.1 cupin domain-containing protein -
EL338_RS20625 4290160..4291860 + 1701 WP_126335449.1 DEAD/DEAH box helicase -
EL338_RS20635 4292460..4292696 + 237 WP_126335450.1 antitoxin Antitoxin
EL338_RS20640 4292683..4293033 + 351 WP_126335451.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL338_RS20645 4293123..4293941 - 819 WP_126335452.1 adenylate/guanylate cyclase domain-containing protein -
EL338_RS20650 4293981..4294478 - 498 WP_126335453.1 polyketide cyclase -
EL338_RS20655 4294531..4295346 - 816 WP_126335454.1 HAD-IIA family hydrolase -
EL338_RS20660 4295379..4296830 - 1452 WP_126335455.1 PH domain-containing protein -
EL338_RS20665 4296827..4297303 - 477 WP_126336996.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12207.17 Da        Isoelectric Point: 10.6484

>T287808 WP_126335451.1 NZ_LR134355:4292683-4293033 [Mycolicibacterium chitae]
MASTEDPRRGQLWLVALGAARPGEPGKHRPAVIVSTEQLLTGEAAELVVVVPVSSSRVATPLRPTLTAADGVDADSVAVC
RAVRGVARARLVRRLGTLSESTMGQVDRALKMILDL

Download         Length: 351 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8399.14 Da        Isoelectric Point: 4.0834

>AT287808 WP_126335450.1 NZ_LR134355:4292460-4292696 [Mycolicibacterium chitae]
MATATTTIRVPVTVRDRLAAQARERGVSVASLLEEWSARAEREAAFAAERAATLAEADDPNVADEERDWAQADADGLD

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References