Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 2558051..2558739 Replicon chromosome
Accession NZ_LR134355
Organism Mycolicibacterium chitae strain NCTC10485

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL338_RS12055 Protein ID WP_126333967.1
Coordinates 2558051..2558464 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL338_RS12060 Protein ID WP_126333968.1
Coordinates 2558461..2558739 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL338_RS12035 2553962..2554237 - 276 WP_126333963.1 hypothetical protein -
EL338_RS12040 2554514..2555053 - 540 WP_126333964.1 hypothetical protein -
EL338_RS12045 2555360..2556556 + 1197 WP_126333965.1 hypothetical protein -
EL338_RS12050 2556575..2558041 + 1467 WP_126333966.1 wax ester/triacylglycerol synthase family O-acyltransferase -
EL338_RS12055 2558051..2558464 - 414 WP_126333967.1 type II toxin-antitoxin system VapC family toxin Toxin
EL338_RS12060 2558461..2558739 - 279 WP_126333968.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL338_RS12065 2558870..2559688 + 819 WP_126333969.1 TIGR03560 family F420-dependent LLM class oxidoreductase -
EL338_RS12070 2560124..2561824 + 1701 WP_126333970.1 class I poly(R)-hydroxyalkanoic acid synthase -
EL338_RS12075 2561935..2563155 - 1221 WP_126333971.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2552341..2553591 1250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14857.94 Da        Isoelectric Point: 4.7569

>T287807 WP_126333967.1 NZ_LR134355:c2558464-2558051 [Mycolicibacterium chitae]
MIYLDTSALTKLLVAEAETPDLQSWLLEQRDHGEDHAVTSALGRVELMRAVARLGEPGLHERALYLLDGLDILPLTDAVI
TLAETIGPARLRSLDAIHLASAAQIRRELTTFVTYDHRLLEGCRAVGFDTASPGGSA

Download         Length: 414 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10349.70 Da        Isoelectric Point: 5.2187

>AT287807 WP_126333968.1 NZ_LR134355:c2558739-2558461 [Mycolicibacterium chitae]
MEAIGVRELRQHASRYLARVEAGEELGVTNNGRLVARLVPVQDVERSRESLIEAGVLTPANRPRNLFDIIATPDPGRERT
LSEVLSEMRDER

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References