Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2550742..2551277 Replicon chromosome
Accession NZ_LR134355
Organism Mycolicibacterium chitae strain NCTC10485

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag EL338_RS12020 Protein ID WP_126333961.1
Coordinates 2550945..2551277 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EL338_RS12015 Protein ID WP_126333960.1
Coordinates 2550742..2550948 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL338_RS11985 2546871..2547485 + 615 WP_126336824.1 hypothetical protein -
EL338_RS11990 2547600..2547845 + 246 WP_126333955.1 plasmid stabilization protein -
EL338_RS11995 2547842..2548270 + 429 WP_126333956.1 type II toxin-antitoxin system VapC family toxin -
EL338_RS12000 2548399..2548608 - 210 WP_126333957.1 hypothetical protein -
EL338_RS12005 2548806..2549813 - 1008 WP_126333958.1 zinc-dependent alcohol dehydrogenase family protein -
EL338_RS12010 2550071..2550622 - 552 WP_126333959.1 YaeQ family protein -
EL338_RS12015 2550742..2550948 + 207 WP_126333960.1 DUF3018 family protein Antitoxin
EL338_RS12020 2550945..2551277 + 333 WP_126333961.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL338_RS12025 2551829..2552254 - 426 WP_126333962.1 hypothetical protein -
EL338_RS12030 2552341..2553591 - 1251 WP_126333404.1 IS256 family transposase -
EL338_RS12035 2553962..2554237 - 276 WP_126333963.1 hypothetical protein -
EL338_RS12040 2554514..2555053 - 540 WP_126333964.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2545469..2546719 1250
- flank IS/Tn - - 2552341..2553591 1250


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11876.67 Da        Isoelectric Point: 7.2039

>T287806 WP_126333961.1 NZ_LR134355:2550945-2551277 [Mycolicibacterium chitae]
VNRGEIWTVAGGIYAGKSRPAVIVQDDLFDATGSVTVAPMTSTLLDAPLMRIRITGGQGRLSGLDHDSDVMIDQLTTVRR
SNVHVRVGRLTAEQVVEVERAMMAFLGLAR

Download         Length: 333 bp

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7973.77 Da        Isoelectric Point: 4.6286

>AT287806 WP_126333960.1 NZ_LR134355:2550742-2550948 [Mycolicibacterium chitae]
MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTESFAAEAHRQASLVARADESNDDQDFIEAVSTPWDEE

Download         Length: 207 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References