Detailed information of TA system TA287806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 2550742..2551277
• Replicon: chromosome
• Accession: NZ_LR134355
• Organism: Mycolicibacterium chitae strain NCTC10485

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: EL338_RS12020
• Protein ID: WP_126333961.1
• Coordinates: 2550945..2551277 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: EL338_RS12015
• Protein ID: WP_126333960.1
• Coordinates: 2550742..2550948 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL338_RS11985	2546871..2547485	+	615	WP_126336824.1	hypothetical protein	-
EL338_RS11990	2547600..2547845	+	246	WP_126333955.1	plasmid stabilization protein	-
EL338_RS11995	2547842..2548270	+	429	WP_126333956.1	type II toxin-antitoxin system VapC family toxin	-
EL338_RS12000	2548399..2548608	-	210	WP_126333957.1	hypothetical protein	-
EL338_RS12005	2548806..2549813	-	1008	WP_126333958.1	zinc-dependent alcohol dehydrogenase family protein	-
EL338_RS12010	2550071..2550622	-	552	WP_126333959.1	YaeQ family protein	-
EL338_RS12015	2550742..2550948	+	207	WP_126333960.1	DUF3018 family protein	Antitoxin
EL338_RS12020	2550945..2551277	+	333	WP_126333961.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
EL338_RS12025	2551829..2552254	-	426	WP_126333962.1	hypothetical protein	-
EL338_RS12030	2552341..2553591	-	1251	WP_126333404.1	IS256 family transposase	-
EL338_RS12035	2553962..2554237	-	276	WP_126333963.1	hypothetical protein	-
EL338_RS12040	2554514..2555053	-	540	WP_126333964.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2545469..2546719	1250
	-	flank	IS/Tn	-	-	2552341..2553591	1250

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-105)

Antitoxin

• Antitoxin MazE-like (4-66)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11876.67 Da
• Isoelectric Point: 7.2039

>T287806 WP_126333961.1 NZ_LR134355:2550945-2551277 [Mycolicibacterium chitae]
VNRGEIWTVAGGIYAGKSRPAVIVQDDLFDATGSVTVAPMTSTLLDAPLMRIRITGGQGRLSGLDHDSDVMIDQLTTVRR
SNVHVRVGRLTAEQVVEVERAMMAFLGLAR

Nucleotide

• Length: 333 bp

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7973.77 Da
• Isoelectric Point: 4.6286

>AT287806 WP_126333960.1 NZ_LR134355:2550742-2550948 [Mycolicibacterium chitae]
MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTESFAAEAHRQASLVARADESNDDQDFIEAVSTPWDEE

Nucleotide

• Length: 207 bp