Detailed information of TA system TA287805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2510164..2511160
• Replicon: chromosome
• Accession: NZ_LR134355
• Organism: Mycolicibacterium chitae strain NCTC10485

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: EL338_RS11780
• Protein ID: WP_126333916.1
• Coordinates: 2510164..2510742 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: EL338_RS11785
• Protein ID: WP_126333917.1
• Coordinates: 2510771..2511160 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL338_RS11760	2505788..2506291	-	504	WP_126333912.1	pyridoxamine 5'-phosphate oxidase family protein	-
EL338_RS11765	2506288..2506887	-	600	WP_126333913.1	TetR/AcrR family transcriptional regulator	-
EL338_RS11770	2506914..2508347	-	1434	WP_126333914.1	rifampin monooxygenase	-
EL338_RS11775	2508505..2510085	-	1581	WP_126333915.1	serine hydrolase	-
EL338_RS11780	2510164..2510742	-	579	WP_126333916.1	zeta toxin family protein	Toxin
EL338_RS11785	2510771..2511160	-	390	WP_126333917.1	hypothetical protein	Antitoxin
EL338_RS11790	2511233..2511829	-	597	WP_126336822.1	FKBP-type peptidyl-prolyl cis-trans isomerase	-
EL338_RS26145	2511945..2512103	-	159	WP_170217437.1	hypothetical protein	-
EL338_RS11795	2512265..2512741	+	477	WP_126333918.1	transcriptional repressor	-
EL338_RS11800	2512731..2514980	+	2250	WP_126333919.1	catalase/peroxidase HPI	-
EL338_RS11805	2515057..2515596	+	540	WP_126333920.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-145)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21002.99 Da
• Isoelectric Point: 8.9334

>T287805 WP_126333916.1 NZ_LR134355:c2510742-2510164 [Mycolicibacterium chitae]
MKRLDLVIGCNGAGKSTFVELTLAPLLPGSAFVNADEIAKRRWPADAAEHAYEAARTAAATRARLIELGESFIAETVFSH
PSKLELVDTALAAGYVVALHVVLIPEELAVLRVAHRVTAGGHAVPENKIRERYGRVWELAARAAQRVDSATFYDNSTRRG
PRIVAQLHGGFIVGQPRWPDWTPTAFTDRWPA

Nucleotide

• Length: 579 bp

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13886.32 Da
• Isoelectric Point: 4.7561

>AT287805 WP_126333917.1 NZ_LR134355:c2511160-2510771 [Mycolicibacterium chitae]
MTDTTDRVTRFAADLVDAAAVEGARQSRSAKQQLDHWARVGRAVSSQHSAARRKVEAALAGETPLRNLSPEEGVAFNAEI
TAALEENLARTDYGQILADRGVTTVALDDDGQIVQYRPDGTTAVLEPRP

Nucleotide

• Length: 390 bp