Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 1896023..1896642 Replicon chromosome
Accession NZ_LR134355
Organism Mycolicibacterium chitae strain NCTC10485

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL338_RS08960 Protein ID WP_126336755.1
Coordinates 1896265..1896642 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL338_RS08955 Protein ID WP_126333443.1
Coordinates 1896023..1896241 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL338_RS08930 1891829..1892779 + 951 WP_126333438.1 alpha/beta fold hydrolase -
EL338_RS08935 1892776..1893402 + 627 WP_126333439.1 TetR/AcrR family transcriptional regulator -
EL338_RS08940 1893404..1893949 - 546 WP_163792083.1 DUF4333 domain-containing protein -
EL338_RS08945 1893949..1895388 - 1440 WP_126333441.1 peptidase -
EL338_RS08950 1895490..1895996 + 507 WP_126333442.1 O-acetyl-ADP-ribose deacetylase -
EL338_RS08955 1896023..1896241 + 219 WP_126333443.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
EL338_RS08960 1896265..1896642 + 378 WP_126336755.1 PIN domain-containing protein Toxin
EL338_RS08965 1896683..1897630 + 948 WP_126333444.1 mechanosensitive ion channel family protein -
EL338_RS08970 1897634..1899253 - 1620 WP_126333445.1 peptide chain release factor 3 -
EL338_RS08975 1899445..1899735 + 291 WP_126333446.1 hypothetical protein -
EL338_RS08980 1899761..1900597 + 837 WP_126333447.1 universal stress protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(2-123)

Antitoxin

Post-segregation antitoxin CcdA

(3-46)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13377.43 Da        Isoelectric Point: 6.7266

>T287804 WP_126336755.1 NZ_LR134355:1896265-1896642 [Mycolicibacterium chitae]
VVIDASAMVDLVARTDRFAAVRARLARTVMHAPAHFDAEVLSALGRLQRAAVLTVAEVDAALDELRQAPVTRHALPSLLS
GAWARRDTLRLADALYVELAETAGLTLLTTDQRLARAAQVADVIA

Download         Length: 378 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 7801.65 Da        Isoelectric Point: 4.3939

>AT287804 WP_126333443.1 NZ_LR134355:1896023-1896241 [Mycolicibacterium chitae]
MARLNVYVPDELAERARARGLNVSALTQAAIRAELDDSATDAWLEALAPRSTRARHDDVLDAIDAARDELGA

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References