Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1889233..1889876 Replicon chromosome
Accession NZ_LR134355
Organism Mycolicibacterium chitae strain NCTC10485

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag EL338_RS08920 Protein ID WP_126333436.1
Coordinates 1889487..1889876 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL338_RS08915 Protein ID WP_126333435.1
Coordinates 1889233..1889487 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL338_RS08885 1884981..1885352 - 372 WP_126333430.1 STAS/SEC14 domain-containing protein -
EL338_RS08890 1885442..1886110 + 669 WP_126333431.1 thioredoxin domain-containing protein -
EL338_RS08895 1886121..1886432 - 312 WP_126336754.1 hypothetical protein -
EL338_RS08900 1886547..1887992 - 1446 WP_126333432.1 ADP-ribosylglycohydrolase family protein -
EL338_RS08905 1888011..1888346 - 336 WP_126333433.1 DUF732 domain-containing protein -
EL338_RS08910 1888583..1889185 + 603 WP_126333434.1 DUF2510 domain-containing protein -
EL338_RS08915 1889233..1889487 + 255 WP_126333435.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EL338_RS08920 1889487..1889876 + 390 WP_126333436.1 type II toxin-antitoxin system VapC family toxin Toxin
EL338_RS08925 1890468..1891832 + 1365 WP_126333437.1 NAD(P)-binding domain-containing protein -
EL338_RS08930 1891829..1892779 + 951 WP_126333438.1 alpha/beta fold hydrolase -
EL338_RS08935 1892776..1893402 + 627 WP_126333439.1 TetR/AcrR family transcriptional regulator -
EL338_RS08940 1893404..1893949 - 546 WP_163792083.1 DUF4333 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13945.75 Da        Isoelectric Point: 4.5486

>T287803 WP_126333436.1 NZ_LR134355:1889487-1889876 [Mycolicibacterium chitae]
MVIDTSALVAMLTDEADAVLLEARVAEDPVRTMSTASYLETAIVIEARYGEAGGRELDLWLHRASVDLVPVTADQAEVAR
RAYRQYGKGCHPAGLNYGDCFSYALAKVNGQPLLFKGDGFQHTDVVAAQ

Download         Length: 390 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9295.66 Da        Isoelectric Point: 7.9886

>AT287803 WP_126333435.1 NZ_LR134355:1889233-1889487 [Mycolicibacterium chitae]
MALSIKDPEADRLARQLAAQTGETLTEVVVVALRERLARQSNRVRVAPLREELAAIRRRCAALEVKDDRAAEAILGYDDR
GLPS

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References