Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-RelB
Location 1831787..1832342 Replicon chromosome
Accession NZ_LR134354
Organism Bifidobacterium longum subsp. infantis strain NCTC11817

Toxin (Protein)


Gene name mazF Uniprot ID B7GSS5
Locus tag EL189_RS09165 Protein ID WP_003833460.1
Coordinates 1832019..1832342 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID S2ZDC4
Locus tag EL189_RS09160 Protein ID WP_003829112.1
Coordinates 1831787..1832032 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL189_RS09140 1827614..1828276 + 663 WP_012577980.1 TetR/AcrR family transcriptional regulator -
EL189_RS09145 1828433..1829704 + 1272 WP_012577981.1 MFS transporter -
EL189_RS09150 1829888..1830092 - 205 Protein_1712 XRE family transcriptional regulator -
EL189_RS09155 1830357..1831613 - 1257 WP_003829116.1 HipA domain-containing protein -
EL189_RS09160 1831787..1832032 + 246 WP_003829112.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL189_RS09165 1832019..1832342 + 324 WP_003833460.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL189_RS09170 1832559..1833173 - 615 WP_012577983.1 cupin domain-containing protein -
EL189_RS09175 1833267..1834136 - 870 WP_003829104.1 class I SAM-dependent methyltransferase -
EL189_RS09180 1834374..1834739 + 366 WP_012577984.1 YccF domain-containing protein -
EL189_RS09190 1835269..1836534 + 1266 WP_012577985.1 Fic family protein -
EL189_RS09200 1837004..1837302 + 299 Protein_1720 IS256 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-106)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-56)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11829.64 Da        Isoelectric Point: 6.2932

>T287800 WP_003833460.1 NZ_LR134354:1832019-1832342 [Bifidobacterium longum subsp. infantis]
MKRGEIRTLQADGYASKPRPVVIVQSDAVDRFDSVITCLLTSYDSSDIDTRVRLEPSPENGLNKVSYVMTDKIVTVDRKL
LGYQVGVVDDAAMANIGRQLMRVLGLL

Download         Length: 324 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9339.43 Da        Isoelectric Point: 4.5881

>AT287800 WP_003829112.1 NZ_LR134354:1831787-1832032 [Bifidobacterium longum subsp. infantis]
MSMQIATRVDDEQAALFKETTRQLGTTPADALRMFISAFNDYRGFPYEVRLPRNDVEPFASERDATEYASRLALRMSDET
R

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0SL31

Antitoxin

Source ID Structure
AlphaFold DB A0A087B6Q6

References