Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 14946..15511 Replicon chromosome
Accession NZ_LR134354
Organism Bifidobacterium longum subsp. infantis strain NCTC11817

Toxin (Protein)


Gene name relE Uniprot ID B7GSH0
Locus tag EL189_RS00065 Protein ID WP_012576472.1
Coordinates 14946..15236 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7GSH1
Locus tag EL189_RS00070 Protein ID WP_012576473.1
Coordinates 15233..15511 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL189_RS00040 10155..10721 + 567 WP_012576468.1 DUF3566 domain-containing protein -
EL189_RS00050 11367..12788 + 1422 WP_012576469.1 ATP-binding protein -
EL189_RS00055 12849..13073 - 225 WP_012576470.1 hypothetical protein -
EL189_RS00060 13224..14570 - 1347 WP_012576471.1 NADP-specific glutamate dehydrogenase -
EL189_RS00065 14946..15236 - 291 WP_012576472.1 type II toxin-antitoxin system YafQ family toxin Toxin
EL189_RS00070 15233..15511 - 279 WP_012576473.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL189_RS00075 15934..16338 + 405 WP_126386265.1 hypothetical protein -
EL189_RS00080 16343..16738 - 396 WP_014484455.1 transposase -
EL189_RS00085 17078..17722 + 645 WP_012576475.1 hypothetical protein -
EL189_RS00090 18144..18335 - 192 WP_126386268.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10835.59 Da        Isoelectric Point: 10.3137

>T287795 WP_012576472.1 NZ_LR134354:c15236-14946 [Bifidobacterium longum subsp. infantis]
MSGIRYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECYITPDLLLVYLIEKDVL
VLTLTRTGTHSGLFGK

Download         Length: 291 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10202.63 Da        Isoelectric Point: 6.3216

>AT287795 WP_012576473.1 NZ_LR134354:c15511-15233 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFGELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B7GSH0

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8MHE5

References