Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1851941..1852577 Replicon chromosome
Accession NZ_LR134352
Organism Nocardia asteroides strain NCTC11293

Toxin (Protein)


Gene name vapC Uniprot ID U5EBJ0
Locus tag EL493_RS08615 Protein ID WP_019045202.1
Coordinates 1851941..1852348 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U5EM71
Locus tag EL493_RS08620 Protein ID WP_019045203.1
Coordinates 1852338..1852577 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL493_RS08600 1849744..1850730 + 987 WP_019045199.1 M48 family metalloprotease -
EL493_RS08605 1850790..1851752 + 963 WP_022567285.1 DUF4349 domain-containing protein -
EL493_RS08610 1851712..1851939 + 228 WP_019045201.1 DUF167 domain-containing protein -
EL493_RS08615 1851941..1852348 - 408 WP_019045202.1 type II toxin-antitoxin system VapC family toxin Toxin
EL493_RS08620 1852338..1852577 - 240 WP_019045203.1 hypothetical protein Antitoxin
EL493_RS08625 1852611..1853075 - 465 WP_019045204.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
EL493_RS08630 1853092..1853490 + 399 WP_081723256.1 DUF3017 domain-containing protein -
EL493_RS08635 1853483..1854130 - 648 WP_019045206.1 nitroreductase family protein -
EL493_RS08640 1854200..1854577 + 378 WP_019045207.1 helix-turn-helix transcriptional regulator -
EL493_RS08645 1854615..1855577 - 963 WP_019045208.1 DUF2236 domain-containing protein -
EL493_RS08650 1855675..1856373 + 699 WP_126405629.1 TetR/AcrR family transcriptional regulator -
EL493_RS08655 1856377..1857525 - 1149 WP_019045210.1 homoserine O-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(7-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14745.93 Da        Isoelectric Point: 6.6367

>T287793 WP_019045202.1 NZ_LR134352:c1852348-1851941 [Nocardia asteroides]
VASDEYVLDGSAASTALLRKDAVGIAVGRLIETSTCHAPHLIDAEVGNVLRRHERKGLVDPETATIGLRMLATMVDRRYA
HQGWLSEQAWLLRHTITFYDGLYAALAARLDVPLLTSDARLSKAPGLPCRVEVID

Download         Length: 408 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8806.83 Da        Isoelectric Point: 4.7064

>AT287793 WP_019045203.1 NZ_LR134352:c1852577-1852338 [Nocardia asteroides]
MATIQIRDIPDEDAEVFRRRAEAEGMSLQAYMRRELIAAARRRSKTEALAAVREALERDSSAGADRESILSALDDARGE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U5EBJ0

Antitoxin

Source ID Structure
AlphaFold DB U5EM71

References