Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1166306..1166825 Replicon chromosome
Accession NZ_LR134352
Organism Nocardia asteroides strain NCTC11293

Toxin (Protein)


Gene name relE Uniprot ID U5EE58
Locus tag EL493_RS05535 Protein ID WP_019044609.1
Coordinates 1166306..1166575 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U5E529
Locus tag EL493_RS05540 Protein ID WP_019044610.1
Coordinates 1166568..1166825 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL493_RS05525 1164135..1164569 - 435 WP_019044607.1 MarR family transcriptional regulator -
EL493_RS05530 1164971..1166284 + 1314 WP_019044608.1 aminotransferase class V-fold PLP-dependent enzyme -
EL493_RS05535 1166306..1166575 - 270 WP_019044609.1 Txe/YoeB family addiction module toxin Toxin
EL493_RS05540 1166568..1166825 - 258 WP_019044610.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL493_RS05545 1166873..1167340 - 468 WP_081723129.1 flavin reductase family protein -
EL493_RS05550 1167493..1167969 - 477 WP_019044612.1 hypothetical protein -
EL493_RS05555 1168077..1168898 + 822 WP_019044613.1 crotonase/enoyl-CoA hydratase family protein -
EL493_RS05560 1168967..1169485 + 519 WP_036836779.1 MarR family transcriptional regulator -
EL493_RS05565 1169482..1171254 + 1773 WP_019044615.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10122.61 Da        Isoelectric Point: 9.3952

>T287792 WP_019044609.1 NZ_LR134352:c1166575-1166306 [Nocardia asteroides]
MPERKLAFSAYGWETYTSWLVRDRTVLKAANKVIAAALADPFAGIGKPEPLKHHLAGHWSRRVTREHRMIYYVTDSEIVV
IAVGGHYDE

Download         Length: 270 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9375.41 Da        Isoelectric Point: 4.4193

>AT287792 WP_019044610.1 NZ_LR134352:c1166825-1166568 [Nocardia asteroides]
MTALPISTARQNLFKLVQQVNDDHDTVTVVTKSGENAVLVAESDWNSIQETLYVLATHGGVRLLESARDAREGRFEAHEL
IDPDA

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U5EE58

Antitoxin

Source ID Structure
AlphaFold DB U5E529

References