287783

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1972881..1973395 Replicon chromosome
Accession NZ_LR134351
Organism Staphylococcus aureus strain NCTC13811

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag EL160_RS10505 Protein ID WP_000581791.1
Coordinates 1972881..1973090 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag EL160_RS10510 Protein ID WP_000138934.1
Coordinates 1973102..1973395 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL160_RS10485 1968770..1969840 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
EL160_RS10490 1970158..1971360 + 1203 WP_001109939.1 rod shape-determining protein RodA -
EL160_RS10495 1971521..1972204 - 684 Protein_1951 transposase -
EL160_RS10500 1972616..1972753 - 138 WP_000828354.1 hypothetical protein -
EL160_RS10505 1972881..1973090 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
EL160_RS10510 1973102..1973395 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
EL160_RS10515 1973561..1975045 + 1485 WP_000571560.1 cardiolipin synthase -
EL160_RS10520 1975073..1975720 + 648 WP_001187612.1 HD domain-containing protein -
EL160_RS10530 1975877..1976176 + 300 WP_001793952.1 hypothetical protein -
EL160_RS10535 1976333..1977205 - 873 WP_000725802.1 membrane protein insertase YidC -
EL160_RS10540 1977291..1977932 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T287783 WP_000581791.1 NZ_LR134351:c1973090-1972881 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT287783 WP_000138934.1 NZ_LR134351:c1973395-1973102 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References