287782

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1952145..1952674 Replicon chromosome
Accession NZ_LR134351
Organism Staphylococcus aureus strain NCTC13811

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag EL160_RS10410 Protein ID WP_000621176.1
Coordinates 1952145..1952507 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag EL160_RS10415 Protein ID WP_000948331.1
Coordinates 1952504..1952674 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL160_RS10385 1949124..1949894 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
EL160_RS10390 1949869..1950348 - 480 WP_001190825.1 anti-sigma B factor RsbW -
EL160_RS10395 1950350..1950676 - 327 WP_001052491.1 anti-sigma factor antagonist -
EL160_RS10400 1950795..1951796 - 1002 WP_129545277.1 PP2C family protein-serine/threonine phosphatase -
EL160_RS10410 1952145..1952507 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL160_RS10415 1952504..1952674 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
EL160_RS10420 1952759..1953907 - 1149 WP_001281140.1 alanine racemase -
EL160_RS10425 1953973..1954332 - 360 WP_000581197.1 holo-ACP synthase -
EL160_RS10430 1954336..1954827 - 492 WP_001286801.1 PH domain-containing protein -
EL160_RS10435 1954820..1956397 - 1578 WP_001294646.1 PH domain-containing protein -
EL160_RS10440 1956390..1956869 - 480 WP_001287082.1 hypothetical protein -
EL160_RS10445 1957078..1957638 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T287782 WP_000621176.1 NZ_LR134351:c1952507-1952145 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT287782 WP_000948331.1 NZ_LR134351:c1952674-1952504 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References