287778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1696151..1696927 Replicon chromosome
Accession NZ_LR134351
Organism Staphylococcus aureus strain NCTC13811

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag EL160_RS08700 Protein ID WP_000031108.1
Coordinates 1696151..1696303 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag EL160_RS08705 Protein ID WP_001251219.1
Coordinates 1696328..1696927 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL160_RS08685 1692297..1693118 + 822 WP_000669380.1 RluA family pseudouridine synthase -
EL160_RS08690 1693574..1694959 - 1386 WP_000116227.1 class II fumarate hydratase -
EL160_RS08695 1695155..1695550 - 396 WP_000901019.1 hypothetical protein -
EL160_RS08700 1696151..1696303 - 153 WP_000031108.1 hypothetical protein Toxin
EL160_RS08705 1696328..1696927 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
EL160_RS08710 1697086..1697556 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
EL160_RS08715 1697561..1698688 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
EL160_RS08720 1698839..1699561 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
EL160_RS08725 1699554..1701011 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T287778 WP_000031108.1 NZ_LR134351:c1696303-1696151 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT287778 WP_001251219.1 NZ_LR134351:c1696927-1696328 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References