Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1202963..1203529 Replicon chromosome
Accession NZ_LR134348
Organism Bifidobacterium breve strain NCTC11815

Toxin (Protein)


Gene name relE Uniprot ID D4BPQ4
Locus tag EL174_RS05430 Protein ID WP_003829417.1
Coordinates 1203236..1203529 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0L7C7C8
Locus tag EL174_RS05425 Protein ID WP_014483711.1
Coordinates 1202963..1203232 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL174_RS05400 1198712..1199407 - 696 WP_003829410.1 response regulator transcription factor -
EL174_RS05405 1199533..1200048 + 516 WP_013140733.1 hypothetical protein -
EL174_RS05410 1200045..1200935 + 891 WP_003829412.1 hypothetical protein -
EL174_RS05415 1200932..1201612 + 681 WP_003829413.1 ABC transporter ATP-binding protein -
EL174_RS05420 1201609..1202778 + 1170 WP_050755802.1 ABC transporter permease -
EL174_RS05425 1202963..1203232 + 270 WP_014483711.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL174_RS05430 1203236..1203529 + 294 WP_003829417.1 type II toxin-antitoxin system YafQ family toxin Toxin
EL174_RS10420 1203535..1203834 - 300 WP_003829418.1 hypothetical protein -
EL174_RS05440 1204197..1204748 + 552 WP_050755804.1 RNA polymerase sigma factor -
EL174_RS05445 1204782..1205609 + 828 WP_003829422.1 hypothetical protein -
EL174_RS05450 1205742..1206368 + 627 WP_003829423.1 hypothetical protein -
EL174_RS05455 1206365..1207147 + 783 WP_003829424.1 hypothetical protein -
EL174_RS05460 1207200..1208075 + 876 WP_003829425.1 ABC transporter ATP-binding protein -
EL174_RS05465 1208129..1208527 + 399 WP_003829426.1 superoxide dismutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1196865..1222395 25530


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11188.92 Da        Isoelectric Point: 9.8306

>T287767 WP_003829417.1 NZ_LR134348:1203236-1203529 [Bifidobacterium breve]
MLKPDYTAAFQRDIKKLKRKHADLRPLKEVIRLVLEDTADSKEALRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGR

Download         Length: 294 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9860.17 Da        Isoelectric Point: 4.7872

>AT287767 WP_014483711.1 NZ_LR134348:1202963-1203232 [Bifidobacterium breve]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPETMEALDEAKNRLADGKPRFNSA
DEMFDSLGI

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7C7H2

Antitoxin

Source ID Structure
AlphaFold DB A0A0L7C7C8

References