Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1104579..1105836 Replicon chromosome
Accession NZ_LR134342
Organism Pseudomonas aeruginosa strain NCTC10728

Toxin (Protein)


Gene name - Uniprot ID Q9I4U4
Locus tag EL327_RS05455 Protein ID WP_003112528.1
Coordinates 1104579..1105334 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag EL327_RS05460 Protein ID WP_003086329.1
Coordinates 1105468..1105836 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL327_RS05445 1099751..1102294 + 2544 WP_023130142.1 acyl-homoserine-lactone acylase QuiP -
EL327_RS05450 1102449..1103810 - 1362 WP_073654789.1 DNA recombination protein RmuC -
EL327_RS05455 1104579..1105334 - 756 WP_003112528.1 RES family NAD+ phosphorylase Toxin
EL327_RS05460 1105468..1105836 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
EL327_RS05465 1105909..1107195 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
EL327_RS05470 1107251..1108840 - 1590 WP_003145542.1 aldehyde dehydrogenase family protein -
EL327_RS05475 1108919..1109395 + 477 WP_003140638.1 hypothetical protein -
EL327_RS30350 1109398..1109673 - 276 WP_010792073.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28278.42 Da        Isoelectric Point: 7.7294

>T287760 WP_003112528.1 NZ_LR134342:c1105334-1104579 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT287760 WP_003086329.1 NZ_LR134342:c1105836-1105468 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I4U4

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References