Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 162729..163950 Replicon chromosome
Accession NZ_LR134342
Organism Pseudomonas aeruginosa strain NCTC10728

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag EL327_RS00940 Protein ID WP_003102740.1
Coordinates 163372..163950 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL327_RS00935 Protein ID WP_003088112.1
Coordinates 162729..163283 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL327_RS00910 158297..158848 + 552 WP_003450159.1 XRE family transcriptional regulator -
EL327_RS00915 158845..159243 - 399 WP_023089053.1 NADH-quinone oxidoreductase subunit A -
EL327_RS00920 159256..159579 - 324 WP_003102734.1 multidrug efflux SMR transporter -
EL327_RS00925 159910..160371 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
EL327_RS00930 160376..162571 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
EL327_RS00935 162729..163283 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
EL327_RS00940 163372..163950 + 579 WP_003102740.1 HD domain-containing protein Toxin
EL327_RS00945 164059..165246 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
EL327_RS00950 165236..167407 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
EL327_RS00955 167397..168674 - 1278 WP_034024258.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T287759 WP_003102740.1 NZ_LR134342:163372-163950 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT287759 WP_003088112.1 NZ_LR134342:162729-163283 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References