Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3518014..3518665 Replicon chromosome
Accession NZ_LR134340
Organism Escherichia marmotae strain NCTC11133

Toxin (Protein)


Gene name cptA Uniprot ID A0A370V2T3
Locus tag EL192_RS16965 Protein ID WP_000244789.1
Coordinates 3518014..3518418 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U9H610
Locus tag EL192_RS16970 Protein ID WP_000354045.1
Coordinates 3518399..3518665 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL192_RS16945 3513978..3515711 - 1734 WP_000813173.1 single-stranded-DNA-specific exonuclease RecJ -
EL192_RS16950 3515717..3516427 - 711 WP_000715232.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL192_RS16955 3516452..3517348 - 897 WP_000806649.1 site-specific tyrosine recombinase XerD -
EL192_RS16960 3517459..3517980 + 522 WP_001055874.1 flavodoxin FldB -
EL192_RS16965 3518014..3518418 - 405 WP_000244789.1 protein YgfX Toxin
EL192_RS16970 3518399..3518665 - 267 WP_000354045.1 FAD assembly factor SdhE Antitoxin
EL192_RS16975 3518918..3519898 + 981 WP_000886070.1 tRNA-modifying protein YgfZ -
EL192_RS16980 3520045..3520704 - 660 WP_001517030.1 hemolysin III family protein -
EL192_RS16985 3520867..3521178 - 312 WP_001182960.1 N(4)-acetylcytidine aminohydrolase -
EL192_RS16990 3521223..3522656 + 1434 WP_016262505.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15987.93 Da        Isoelectric Point: 11.5202

>T287756 WP_000244789.1 NZ_LR134340:c3518418-3518014 [Escherichia marmotae]
VVLWQSELRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWLVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWSIVKTPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQEIR

Download         Length: 405 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10533.09 Da        Isoelectric Point: 5.1496

>AT287756 WP_000354045.1 NZ_LR134340:c3518665-3518399 [Escherichia marmotae]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A370V2T3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H610

References