Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2256738..2257376 Replicon chromosome
Accession NZ_LR134340
Organism Escherichia marmotae strain NCTC11133

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL192_RS10805 Protein ID WP_016262026.1
Coordinates 2257200..2257376 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL192_RS10800 Protein ID WP_077627724.1
Coordinates 2256738..2257154 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL192_RS10780 2251893..2252834 - 942 WP_001516417.1 ABC transporter permease -
EL192_RS10785 2252835..2253848 - 1014 WP_016248715.1 ABC transporter ATP-binding protein -
EL192_RS10790 2253866..2255011 - 1146 WP_000047463.1 ABC transporter substrate-binding protein -
EL192_RS10795 2255250..2256659 - 1410 WP_016248716.1 PLP-dependent aminotransferase family protein -
EL192_RS10800 2256738..2257154 - 417 WP_077627724.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
EL192_RS10805 2257200..2257376 - 177 WP_016262026.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
EL192_RS10810 2257598..2257828 + 231 WP_000494240.1 DUF2554 family protein -
EL192_RS10815 2257922..2259883 - 1962 WP_024193578.1 23S rRNA 5-hydroxycytidine C2501 synthase -
EL192_RS10820 2259956..2260492 - 537 WP_000429073.1 XRE family transcriptional regulator -
EL192_RS10825 2260545..2261756 + 1212 WP_072024149.1 benzoate/H(+) symporter BenE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6805.83 Da        Isoelectric Point: 11.2292

>T287753 WP_016262026.1 NZ_LR134340:c2257376-2257200 [Escherichia marmotae]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLDLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15250.62 Da        Isoelectric Point: 4.5908

>AT287753 WP_077627724.1 NZ_LR134340:c2257154-2256738 [Escherichia marmotae]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNNNDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References