Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2173893..2175481 Replicon chromosome
Accession NZ_LR134340
Organism Escherichia marmotae strain NCTC11133

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL192_RS10475 Protein ID WP_016262007.1
Coordinates 2174159..2175481 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL192_RS10470 Protein ID WP_016262006.1
Coordinates 2173893..2174159 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL192_RS10455 2170561..2171475 + 915 WP_016262004.1 bestrophin family protein -
EL192_RS10460 2171479..2172237 - 759 WP_016262005.1 trans-aconitate 2-methyltransferase -
EL192_RS10465 2172673..2173629 + 957 WP_000197006.1 hypothetical protein -
EL192_RS10470 2173893..2174159 + 267 WP_016262006.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
EL192_RS10475 2174159..2175481 + 1323 WP_016262007.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
EL192_RS10480 2175890..2176747 + 858 WP_001516370.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2172673..2185842 13169


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49655.34 Da        Isoelectric Point: 8.8782

>T287752 WP_016262007.1 NZ_LR134340:2174159-2175481 [Escherichia marmotae]
MPKLVTWMNNQRVGELTKLTNGAHTFKYAPEWLTNRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPEDETVTRPIMVWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRMGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKEFGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGSTDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGRKTEIDKIYPRHFLATAKALKFPEVQMHEILRDFARMIP
AALDNVKASLPADFPENVLTAIETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10018.41 Da        Isoelectric Point: 4.8778

>AT287752 WP_016262006.1 NZ_LR134340:2173893-2174159 [Escherichia marmotae]
MMSFPMIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLNLSMTLCDTKNDSPES
TVQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References