Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5718404..5719057 Replicon chromosome
Accession NZ_LR134338
Organism Brevibacillus brevis strain NCTC2611

Toxin (Protein)


Gene name mazF Uniprot ID J2PLP3
Locus tag EL268_RS27730 Protein ID WP_005830205.1
Coordinates 5718404..5718754 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID J2GZH3
Locus tag EL268_RS27735 Protein ID WP_007721089.1
Coordinates 5718758..5719057 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL268_RS27705 5715158..5715946 - 789 WP_007721066.1 RNA polymerase sigma factor SigB -
EL268_RS27710 5715915..5716409 - 495 WP_106652694.1 anti-sigma B factor RsbW -
EL268_RS27715 5716409..5716735 - 327 WP_106652693.1 anti-sigma factor antagonist -
EL268_RS27720 5716760..5717761 - 1002 WP_106652692.1 PP2C family protein-serine/threonine phosphatase -
EL268_RS27725 5717767..5718195 - 429 WP_106652691.1 anti-sigma regulatory factor -
EL268_RS27730 5718404..5718754 - 351 WP_005830205.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL268_RS27735 5718758..5719057 - 300 WP_007721089.1 CopG family ribbon-helix-helix protein Antitoxin
EL268_RS27740 5719288..5720490 - 1203 WP_106652690.1 alanine racemase -
EL268_RS27745 5720493..5720933 - 441 WP_106652689.1 hypothetical protein -
EL268_RS27750 5721118..5722200 - 1083 WP_106652688.1 hypothetical protein -
EL268_RS27755 5722336..5722527 + 192 WP_106652687.1 hypothetical protein -
EL268_RS27760 5722904..5723941 - 1038 WP_106652686.1 outer membrane lipoprotein-sorting protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-52)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12917.86 Da        Isoelectric Point: 4.8435

>T287743 WP_005830205.1 NZ_LR134338:c5718754-5718404 [Brevibacillus brevis]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGFDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMDRVNESLQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11309.19 Da        Isoelectric Point: 10.2101

>AT287743 WP_007721089.1 NZ_LR134338:c5719057-5718758 [Brevibacillus brevis]
MVGGGFVLSKSNTKRIMISLPQHLLQEVDGVIQKEKSNRSEFIRQAMHLYLKERKKRTIRETMQKGYMEMAKINLNMASE
AFGAEEEADHTLVRLVSGV

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2PLP3

Antitoxin

Source ID Structure
AlphaFold DB J2GZH3

References