287740

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 173707..174236 Replicon chromosome
Accession NZ_LR134337
Organism Enterococcus faecium strain NCTC7174

Toxin (Protein)


Gene name relE Uniprot ID A0A2D0BMD7
Locus tag EL154_RS00910 Protein ID WP_002319468.1
Coordinates 173970..174236 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag EL154_RS00905 Protein ID WP_002294199.1
Coordinates 173707..173970 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL154_RS00890 171082..172905 + 1824 WP_002294202.1 APC family permease -
EL154_RS00895 173047..173232 - 186 WP_002294201.1 hypothetical protein -
EL154_RS00905 173707..173970 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EL154_RS00910 173970..174236 + 267 WP_002319468.1 Txe/YoeB family addiction module toxin Toxin
EL154_RS00915 174437..174925 + 489 WP_010723470.1 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase -
EL154_RS00920 175467..176138 - 672 WP_002319469.1 ABC transporter permease -
EL154_RS00925 176135..177052 - 918 WP_002319470.1 osmoprotectant ABC transporter substrate-binding protein -
EL154_RS00930 177049..177690 - 642 WP_002293405.1 ABC transporter permease -
EL154_RS00935 177694..178869 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10632.08 Da        Isoelectric Point: 9.9931

>T287740 WP_002319468.1 NZ_LR134337:173970-174236 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVAEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT287740 WP_002294199.1 NZ_LR134337:173707-173970 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2D0BMD7

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References