Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3532466..3533138 Replicon chromosome
Accession NZ_LR134335
Organism Yersinia enterocolitica subsp. palearctica strain NCTC13769

Toxin (Protein)


Gene name cptA Uniprot ID A0A7U7FIQ4
Locus tag EL202_RS16635 Protein ID WP_005166047.1
Coordinates 3532713..3533138 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7U7FJE4
Locus tag EL202_RS16630 Protein ID WP_004390965.1
Coordinates 3532466..3532732 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL202_RS16610 3528064..3528666 - 603 WP_005164134.1 HD domain-containing protein -
EL202_RS16615 3528897..3529580 + 684 WP_005180855.1 hemolysin III family protein -
EL202_RS16620 3529992..3531011 - 1020 WP_129546912.1 IS110 family transposase -
EL202_RS16625 3531207..3532199 - 993 WP_005166051.1 tRNA-modifying protein YgfZ -
EL202_RS16630 3532466..3532732 + 267 WP_004390965.1 FAD assembly factor SdhE Antitoxin
EL202_RS16635 3532713..3533138 + 426 WP_005166047.1 protein YgfX Toxin
EL202_RS16640 3533138..3533836 + 699 WP_005166045.1 two-component system response regulator CreB -
EL202_RS16645 3533847..3535269 + 1423 Protein_3130 two-component system sensor histidine kinase CreC -
EL202_RS16650 3535361..3536782 + 1422 WP_005166043.1 cell envelope integrity protein CreD -
EL202_RS16655 3536841..3537359 - 519 WP_005166042.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3529992..3531011 1019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16425.21 Da        Isoelectric Point: 9.8217

>T287737 WP_005166047.1 NZ_LR134335:3532713-3533138 [Yersinia enterocolitica subsp. palearctica]
VAQWRCDLRISWHTQLFSLLAHGVLVTLTLVAPWPQGYTALWLVLLTLVVFECIRSQKNITSCQGEIRLKPGNIVLWKRH
EWVVIKQPWITRYGVLLSLQQTSSRSTRKRLWLAADSMSEEEWRQLCLLLRHSFGSDEGIN

Download         Length: 426 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10491.01 Da        Isoelectric Point: 5.1405

>AT287737 WP_004390965.1 NZ_LR134335:3532466-3532732 [Yersinia enterocolitica subsp. palearctica]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDGLSDNEKQVFIRLLECDDPDLFNWLMNHGEPQDSELRQMVKLIQTRN
KARGPVAM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FIQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FJE4

References