Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 6562615..6563234 Replicon chromosome
Accession NZ_LR134334
Organism Pseudomonas chlororaphis strain NCTC7357

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G7DMG3
Locus tag EL332_RS29500 Protein ID WP_009048155.1
Coordinates 6563052..6563234 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A285IZU0
Locus tag EL332_RS29495 Protein ID WP_007923747.1
Coordinates 6562615..6563016 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL332_RS29480 6558685..6560574 + 1890 WP_124304744.1 PAS domain S-box protein -
EL332_RS29485 6560571..6561206 + 636 WP_124304745.1 response regulator transcription factor -
EL332_RS29490 6561300..6562049 + 750 WP_124304746.1 hypothetical protein -
EL332_RS29495 6562615..6563016 - 402 WP_007923747.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL332_RS29500 6563052..6563234 - 183 WP_009048155.1 type II toxin-antitoxin system HicA family toxin Toxin
EL332_RS29505 6563526..6563807 - 282 WP_124304747.1 hypothetical protein -
EL332_RS29510 6564451..6566610 - 2160 WP_164486009.1 AAA family ATPase -
EL332_RS29515 6566951..6567499 - 549 WP_124304749.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6799.98 Da        Isoelectric Point: 10.9678

>T287722 WP_009048155.1 NZ_LR134334:c6563234-6563052 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLI

Download         Length: 183 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14579.54 Da        Isoelectric Point: 4.6017

>AT287722 WP_007923747.1 NZ_LR134334:c6563016-6562615 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPTGTHRANPDFEGMGWGM
LDIDITPYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G7DMG3

Antitoxin

Source ID Structure
AlphaFold DB A0A285IZU0

References