Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5732885..5733507 Replicon chromosome
Accession NZ_LR134334
Organism Pseudomonas chlororaphis strain NCTC7357

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL332_RS25760 Protein ID WP_106696706.1
Coordinates 5733325..5733507 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL332_RS25755 Protein ID WP_106698998.1
Coordinates 5732885..5733292 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL332_RS25735 5728187..5729080 + 894 WP_173678573.1 LysR family transcriptional regulator -
EL332_RS25740 5729316..5731094 + 1779 WP_124323664.1 GGDEF and EAL domain-containing protein -
EL332_RS25745 5731128..5732042 - 915 WP_124323665.1 SGNH/GDSL hydrolase family protein -
EL332_RS25750 5732172..5732639 - 468 WP_106696705.1 GAF domain-containing protein -
EL332_RS25755 5732885..5733292 - 408 WP_106698998.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL332_RS25760 5733325..5733507 - 183 WP_106696706.1 type II toxin-antitoxin system HicA family toxin Toxin
EL332_RS25770 5734226..5735110 - 885 WP_009047472.1 alpha/beta hydrolase -
EL332_RS25775 5735462..5736154 - 693 WP_025804997.1 16S rRNA pseudouridine(516) synthase -
EL332_RS25780 5736188..5736421 - 234 WP_106696707.1 cysteine-rich CWC family protein -
EL332_RS25785 5736414..5737901 - 1488 WP_106696708.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6810.12 Da        Isoelectric Point: 11.6709

>T287721 WP_106696706.1 NZ_LR134334:c5733507-5733325 [Pseudomonas chlororaphis]
VNSRYLIGQIVADGWYLVRVRGSHHPFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14657.65 Da        Isoelectric Point: 4.4710

>AT287721 WP_106698998.1 NZ_LR134334:c5733292-5732885 [Pseudomonas chlororaphis]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAAIPPANKVTLHAANPQYAGRTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References