287716

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 5456344..5457047 Replicon chromosome
Accession NZ_LR134333
Organism Klebsiella oxytoca strain NCTC13727

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag EL226_RS25850 Protein ID WP_064406970.1
Coordinates 5456344..5456685 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag EL226_RS25855 Protein ID WP_073971812.1
Coordinates 5456706..5457047 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL226_RS25825 5451963..5452757 + 795 WP_053064564.1 DNA/RNA non-specific endonuclease -
EL226_RS25830 5453047..5453370 + 324 WP_049102104.1 endoribonuclease SymE -
EL226_RS25835 5453517..5453951 + 435 WP_032728836.1 VOC family protein -
EL226_RS25840 5454105..5454848 + 744 WP_049102101.1 hypothetical protein -
EL226_RS25845 5455078..5456085 - 1008 WP_064406969.1 restriction endonuclease -
EL226_RS25850 5456344..5456685 - 342 WP_064406970.1 TA system toxin CbtA family protein Toxin
EL226_RS25855 5456706..5457047 - 342 WP_073971812.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EL226_RS25860 5457058..5457600 - 543 WP_064406972.1 DNA repair protein RadC -
EL226_RS25865 5457613..5458056 - 444 WP_064406973.1 antirestriction protein -
EL226_RS25870 5458087..5458908 - 822 WP_064406974.1 DUF945 domain-containing protein -
EL226_RS25875 5459029..5459502 - 474 WP_064406975.1 hypothetical protein -
EL226_RS25880 5459550..5460002 - 453 WP_064406976.1 hypothetical protein -
EL226_RS25885 5460038..5460754 - 717 WP_064406977.1 WYL domain-containing protein -
EL226_RS25890 5460998..5461873 - 876 WP_064406978.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5453517..5470755 17238


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(13-111)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12700.63 Da        Isoelectric Point: 8.9919

>T287716 WP_064406970.1 NZ_LR134333:c5456685-5456344 [Klebsiella oxytoca]
MKTLPATNPQAATLCLPPVAGWQMLLARLLEQHYGLTLNDTPFSDEKVIQEHIDAGISLADAANFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12746.37 Da        Isoelectric Point: 6.7345

>AT287716 WP_073971812.1 NZ_LR134333:c5457047-5456706 [Klebsiella oxytoca]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECFKLDVAFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYSTHR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References