287714

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4672393..4673012 Replicon chromosome
Accession NZ_LR134333
Organism Klebsiella oxytoca strain NCTC13727

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag EL226_RS22250 Protein ID WP_004099646.1
Coordinates 4672794..4673012 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag EL226_RS22245 Protein ID WP_004099648.1
Coordinates 4672393..4672767 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL226_RS22235 4667549..4668742 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EL226_RS22240 4668765..4671911 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit -
EL226_RS22245 4672393..4672767 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
EL226_RS22250 4672794..4673012 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
EL226_RS22255 4673173..4673739 + 567 WP_004099644.1 maltose O-acetyltransferase -
EL226_RS22260 4673876..4674346 + 471 WP_004111038.1 YlaC family protein -
EL226_RS22265 4674321..4675775 - 1455 WP_024273853.1 PLP-dependent aminotransferase family protein -
EL226_RS22270 4675878..4676576 + 699 WP_004099639.1 GNAT family N-acetyltransferase -
EL226_RS22275 4676573..4676713 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EL226_RS22280 4676713..4676976 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T287714 WP_004099646.1 NZ_LR134333:4672794-4673012 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT287714 WP_004099648.1 NZ_LR134333:4672393-4672767 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References