Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1188300..1188957 Replicon chromosome
Accession NZ_LR134333
Organism Klebsiella oxytoca strain NCTC13727

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag EL226_RS05770 Protein ID WP_004105559.1
Coordinates 1188547..1188957 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag EL226_RS05765 Protein ID WP_004105561.1
Coordinates 1188300..1188566 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL226_RS05740 1183480..1184913 - 1434 WP_004105576.1 6-phospho-beta-glucosidase -
EL226_RS05745 1185034..1185762 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
EL226_RS05750 1185813..1186124 + 312 WP_017145456.1 N(4)-acetylcytidine aminohydrolase -
EL226_RS05755 1186286..1186945 + 660 WP_004105569.1 hemolysin III family protein -
EL226_RS05760 1187073..1188056 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
EL226_RS05765 1188300..1188566 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
EL226_RS05770 1188547..1188957 + 411 WP_004105559.1 protein YgfX Toxin
EL226_RS05775 1188966..1189487 - 522 WP_004105557.1 flavodoxin FldB -
EL226_RS05780 1189609..1190505 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
EL226_RS05785 1190528..1191241 + 714 WP_064406949.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EL226_RS05790 1191247..1192980 + 1734 WP_004105553.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T287709 WP_004105559.1 NZ_LR134333:1188547-1188957 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT287709 WP_004105561.1 NZ_LR134333:1188300-1188566 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References