Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2500048..2500610 Replicon chromosome
Accession NZ_LR134331
Organism Lacticaseibacillus rhamnosus strain NCTC13764

Toxin (Protein)


Gene name mazF Uniprot ID C2JYM4
Locus tag EL173_RS12540 Protein ID WP_005692155.1
Coordinates 2500048..2500395 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EL173_RS12545 Protein ID WP_014571589.1
Coordinates 2500395..2500610 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL173_RS12510 2495543..2496784 - 1242 WP_005692160.1 acyltransferase -
EL173_RS12515 2496781..2497482 - 702 WP_005692159.1 ABC transporter ATP-binding protein -
EL173_RS12520 2497475..2498293 - 819 WP_014571588.1 ABC transporter permease subunit -
EL173_RS12525 2498534..2499202 - 669 WP_005692157.1 tRNA ligase -
EL173_RS12530 2499382..2499525 + 144 WP_015764720.1 hypothetical protein -
EL173_RS12540 2500048..2500395 - 348 WP_005692155.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL173_RS12545 2500395..2500610 - 216 WP_014571589.1 hypothetical protein Antitoxin
EL173_RS12550 2500707..2502542 - 1836 WP_015764721.1 ABC transporter ATP-binding protein/permease -
EL173_RS12555 2502529..2504319 - 1791 WP_015764722.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13150.01 Da        Isoelectric Point: 7.9817

>T287705 WP_005692155.1 NZ_LR134331:c2500395-2500048 [Lacticaseibacillus rhamnosus]
MTYKAKQGDVVWLDFDPSEGHEIRKRCPAVVLSSNAYNRATGFVIVAPITSTIRTLPGYVDIVSNKIRGQVVTSQVYSLD
VTEQGNRKIDFIERMNIEDFYTVAQFTKMNFDFKF

Download         Length: 348 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7986.13 Da        Isoelectric Point: 5.7995

>AT287705 WP_014571589.1 NZ_LR134331:c2500610-2500395 [Lacticaseibacillus rhamnosus]
MDVKVVKRGNSLALSLPSSAGFKRGEAFLLISDEKGGYLLIPKVKNPYTKAKPLSFHQEEAWPDFDYEDIE

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9DS75

Antitoxin

Source ID Structure

References