Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 5537198..5538418 | Replicon | chromosome |
| Accession | NZ_LR134330 | ||
| Organism | Pseudomonas aeruginosa strain NCTC13715 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | EL342_RS26280 | Protein ID | WP_003118970.1 |
| Coordinates | 5537840..5538418 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | EL342_RS26275 | Protein ID | WP_003132728.1 |
| Coordinates | 5537198..5537752 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EL342_RS26250 | 5532766..5533317 | + | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
| EL342_RS26255 | 5533314..5533712 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| EL342_RS26260 | 5533725..5534048 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| EL342_RS26265 | 5534379..5534840 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| EL342_RS26270 | 5534845..5537040 | + | 2196 | WP_033938086.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| EL342_RS26275 | 5537198..5537752 | + | 555 | WP_003132728.1 | helix-turn-helix domain-containing protein | Antitoxin |
| EL342_RS26280 | 5537840..5538418 | + | 579 | WP_003118970.1 | HD domain-containing protein | Toxin |
| EL342_RS26285 | 5538528..5539715 | - | 1188 | WP_003110489.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| EL342_RS26290 | 5539705..5541876 | - | 2172 | WP_033989048.1 | type I secretion system permease/ATPase | - |
| EL342_RS26295 | 5541866..5542915 | - | 1050 | WP_033938087.1 | TolC family protein | - |
| EL342_RS26300 | 5542974..5543198 | - | 225 | WP_010791890.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lasA | 5529715..5606607 | 76892 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21899.72 Da Isoelectric Point: 5.3655
>T287702 WP_003118970.1 NZ_LR134330:5537840-5538418 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20470.63 Da Isoelectric Point: 8.1590
>AT287702 WP_003132728.1 NZ_LR134330:5537198-5537752 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLESAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|