Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2002233..2002738 Replicon chromosome
Accession NZ_LR134330
Organism Pseudomonas aeruginosa strain NCTC13715

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag EL342_RS09445 Protein ID WP_003083773.1
Coordinates 2002233..2002514 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag EL342_RS09450 Protein ID WP_003083775.1
Coordinates 2002511..2002738 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL342_RS09420 1997484..1998833 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
EL342_RS09425 1998882..1999568 + 687 WP_003083762.1 FadR family transcriptional regulator -
EL342_RS09430 1999669..2000403 + 735 WP_003110658.1 GntR family transcriptional regulator -
EL342_RS09435 2000607..2000993 + 387 WP_003083767.1 aegerolysin family protein -
EL342_RS09440 2001025..2001933 - 909 WP_003083769.1 LysR family transcriptional regulator -
EL342_RS09445 2002233..2002514 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
EL342_RS09450 2002511..2002738 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
EL342_RS09455 2002914..2003534 - 621 WP_003101226.1 hypothetical protein -
EL342_RS09460 2003635..2004135 + 501 WP_003162763.1 LEA type 2 family protein -
EL342_RS09465 2004208..2004549 + 342 WP_003101229.1 alkylphosphonate utilization protein -
EL342_RS09470 2004631..2006058 - 1428 WP_003083784.1 GABA permease -
EL342_RS09475 2006227..2007720 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T287699 WP_003083773.1 NZ_LR134330:c2002514-2002233 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT287699 WP_003083775.1 NZ_LR134330:c2002738-2002511 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References