Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4444156..4444792 Replicon chromosome
Accession NZ_LR134329
Organism Bordetella parapertussis strain NCTC10524

Toxin (Protein)


Gene name hicA Uniprot ID Q7W5Z1
Locus tag EL261_RS21015 Protein ID WP_010928914.1
Coordinates 4444156..4444338 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7W5Z0
Locus tag EL261_RS21020 Protein ID WP_010928915.1
Coordinates 4444400..4444792 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL261_RS20990 4439730..4440407 + 678 WP_010928910.1 HAD-IA family hydrolase -
EL261_RS20995 4440625..4441812 + 1188 WP_010928911.1 MFS transporter -
EL261_RS21005 4442387..4443607 + 1221 WP_010928912.1 ISL3-like element IS1001 family transposase -
EL261_RS21015 4444156..4444338 + 183 WP_010928914.1 type II toxin-antitoxin system HicA family toxin Toxin
EL261_RS21020 4444400..4444792 + 393 WP_010928915.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL261_RS21025 4445065..4445974 - 910 Protein_4123 LysR family transcriptional regulator -
EL261_RS21030 4446099..4447073 + 975 WP_010928916.1 tripartite tricarboxylate transporter substrate binding protein -
EL261_RS21035 4447108..4447467 + 360 WP_010928917.1 hypothetical protein -
EL261_RS21040 4447534..4448706 + 1173 WP_010928918.1 thiolase domain-containing protein -
EL261_RS21045 4448710..4449136 + 427 Protein_4127 OB-fold domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4442387..4443607 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6572.69 Da        Isoelectric Point: 10.9062

>T287697 WP_010928914.1 NZ_LR134329:4444156-4444338 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14058.82 Da        Isoelectric Point: 4.2876

>AT287697 WP_010928915.1 NZ_LR134329:4444400-4444792 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7W5Z1

Antitoxin

Source ID Structure
AlphaFold DB Q7W5Z0

References