Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 3153957..3154488 Replicon chromosome
Accession NZ_LR134329
Organism Bordetella parapertussis strain NCTC10524

Toxin (Protein)


Gene name shpA Uniprot ID K0MH61
Locus tag EL261_RS15010 Protein ID WP_003812626.1
Coordinates 3154222..3154488 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID K0MF02
Locus tag EL261_RS15005 Protein ID WP_003816743.1
Coordinates 3153957..3154235 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL261_RS14980 3149387..3150481 + 1095 WP_003812637.1 TRAP transporter substrate-binding protein -
EL261_RS14985 3150693..3151322 + 630 WP_010928293.1 TRAP transporter small permease subunit -
EL261_RS14990 3151325..3152992 + 1668 WP_010928294.1 TRAP transporter large permease subunit -
EL261_RS14995 3153007..3153663 + 657 WP_010928295.1 phosphoribosylanthranilate isomerase -
EL261_RS15005 3153957..3154235 - 279 WP_003816743.1 BrnA antitoxin family protein Antitoxin
EL261_RS15010 3154222..3154488 - 267 WP_003812626.1 BrnT family toxin Toxin
EL261_RS15015 3154719..3156260 - 1542 WP_010928296.1 M81 family metallopeptidase -
EL261_RS15020 3156322..3157200 - 879 WP_041937387.1 tripartite tricarboxylate transporter substrate binding protein -
EL261_RS15025 3157597..3158229 + 633 WP_003812619.1 PAS domain-containing protein -
EL261_RS15030 3158340..3159050 + 711 WP_003812617.1 aquaporin Z -
EL261_RS15035 3159089..3159361 - 273 WP_003812615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(12-86)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10037.47 Da        Isoelectric Point: 7.9923

>T287694 WP_003812626.1 NZ_LR134329:c3154488-3154222 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Download         Length: 267 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10412.89 Da        Isoelectric Point: 10.5548

>AT287694 WP_003816743.1 NZ_LR134329:c3154235-3153957 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0MH61

Antitoxin

Source ID Structure
AlphaFold DB K0MF02

References