Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2567386..2568047 Replicon chromosome
Accession NZ_LR134329
Organism Bordetella parapertussis strain NCTC10524

Toxin (Protein)


Gene name vapC Uniprot ID Q7WAH5
Locus tag EL261_RS12170 Protein ID WP_003812073.1
Coordinates 2567386..2567811 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL261_RS12175 Protein ID WP_003812071.1
Coordinates 2567808..2568047 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL261_RS12150 2563200..2564177 + 978 WP_003812083.1 tripartite tricarboxylate transporter substrate binding protein -
EL261_RS12155 2564198..2564710 - 513 WP_010928017.1 hypothetical protein -
EL261_RS12160 2565209..2566714 + 1506 WP_010928018.1 tripartite tricarboxylate transporter permease -
EL261_RS12165 2566812..2567276 - 465 WP_003812075.1 MarR family transcriptional regulator -
EL261_RS12170 2567386..2567811 - 426 WP_003812073.1 PIN domain-containing protein Toxin
EL261_RS12175 2567808..2568047 - 240 WP_003812071.1 Arc family DNA-binding protein Antitoxin
EL261_RS12180 2568121..2568963 - 843 WP_010928019.1 AraC family transcriptional regulator -
EL261_RS12185 2569101..2569646 + 546 WP_010928020.1 peroxidase-related enzyme -
EL261_RS12190 2569705..2570217 + 513 WP_003812062.1 redoxin domain-containing protein -
EL261_RS12195 2570298..2570531 + 234 WP_033447224.1 DUF2945 domain-containing protein -
EL261_RS12200 2570528..2571088 + 561 WP_010928021.1 DUF488 domain-containing protein -
EL261_RS12205 2571166..2572212 + 1047 WP_010928022.1 Dyp-type peroxidase -
EL261_RS12210 2572209..2573012 + 804 WP_003812055.1 bacteriocin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14811.22 Da        Isoelectric Point: 6.3704

>T287693 WP_003812073.1 NZ_LR134329:c2567811-2567386 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Download         Length: 426 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8561.78 Da        Isoelectric Point: 11.5658

>AT287693 WP_003812071.1 NZ_LR134329:c2568047-2567808 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7WAH5

Antitoxin

Source ID Structure

References