Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2248300..2248961 Replicon chromosome
Accession NZ_LR134326
Organism Bordetella bronchiseptica strain NCTC10543

Toxin (Protein)


Gene name vapC Uniprot ID Q7WAH5
Locus tag EL288_RS10460 Protein ID WP_003812073.1
Coordinates 2248300..2248725 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EL288_RS10465 Protein ID WP_003812071.1
Coordinates 2248722..2248961 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL288_RS10440 2244114..2245091 + 978 WP_003812083.1 tripartite tricarboxylate transporter substrate binding protein -
EL288_RS10445 2245112..2245624 - 513 WP_003812080.1 hypothetical protein -
EL288_RS10450 2246123..2247628 + 1506 WP_003812078.1 tripartite tricarboxylate transporter permease -
EL288_RS10455 2247726..2248190 - 465 WP_003812075.1 MarR family transcriptional regulator -
EL288_RS10460 2248300..2248725 - 426 WP_003812073.1 PIN domain-containing protein Toxin
EL288_RS10465 2248722..2248961 - 240 WP_003812071.1 Arc family DNA-binding protein Antitoxin
EL288_RS10470 2249035..2249877 - 843 WP_126622041.1 AraC family transcriptional regulator -
EL288_RS10475 2250015..2250560 + 546 WP_003812065.1 peroxidase-related enzyme -
EL288_RS10480 2250619..2251131 + 513 WP_003812062.1 redoxin domain-containing protein -
EL288_RS10485 2251212..2251445 + 234 WP_033447224.1 DUF2945 domain-containing protein -
EL288_RS10490 2251442..2252002 + 561 WP_010926528.1 DUF488 domain-containing protein -
EL288_RS10495 2252080..2253126 + 1047 WP_003812057.1 Dyp-type peroxidase -
EL288_RS10500 2253123..2253926 + 804 WP_003812055.1 bacteriocin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14811.22 Da        Isoelectric Point: 6.3704

>T287688 WP_003812073.1 NZ_LR134326:c2248725-2248300 [Bordetella bronchiseptica]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Download         Length: 426 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8561.78 Da        Isoelectric Point: 11.5658

>AT287688 WP_003812071.1 NZ_LR134326:c2248961-2248722 [Bordetella bronchiseptica]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7WAH5

Antitoxin

Source ID Structure

References