Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2103142..2104741 Replicon chromosome
Accession NZ_LR134326
Organism Bordetella bronchiseptica strain NCTC10543

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EL288_RS09755 Protein ID WP_033459770.1
Coordinates 2103401..2104741 (+) Length 447 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EL288_RS09750 Protein ID WP_019247974.1
Coordinates 2103142..2103399 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL288_RS09735 2101450..2102025 - 576 WP_080704460.1 PIN domain-containing protein -
EL288_RS09740 2102022..2102489 - 468 WP_033459772.1 helix-turn-helix domain-containing protein -
EL288_RS09750 2103142..2103399 + 258 WP_019247974.1 helix-turn-helix domain-containing protein Antitoxin
EL288_RS09755 2103401..2104741 + 1341 WP_033459770.1 type II toxin-antitoxin system HipA family toxin Toxin
EL288_RS09760 2104837..2105526 - 690 WP_033459800.1 TetR/AcrR family transcriptional regulator -
EL288_RS09765 2105539..2106969 + 1431 WP_080703532.1 MFS transporter -
EL288_RS09770 2107207..2108286 + 1080 WP_033459767.1 tellurite resistance/C4-dicarboxylate transporter family protein -
EL288_RS09775 2108578..2109399 + 822 WP_015063659.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2102022..2116495 14473


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 447 a.a.        Molecular weight: 49594.70 Da        Isoelectric Point: 7.4158

>T287687 WP_033459770.1 NZ_LR134326:2103401-2104741 [Bordetella bronchiseptica]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRAAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSSLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Download         Length: 1341 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 8815.04 Da        Isoelectric Point: 7.1642

>AT287687 WP_019247974.1 NZ_LR134326:2103142-2103399 [Bordetella bronchiseptica]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References