Detailed information of TA system TA287686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 2101450..2102489
• Replicon: chromosome
• Accession: NZ_LR134326
• Organism: Bordetella bronchiseptica strain NCTC10543

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: EL288_RS09735
• Protein ID: WP_080704460.1
• Coordinates: 2101450..2102025 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: EL288_RS09740
• Protein ID: WP_033459772.1
• Coordinates: 2102022..2102489 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL288_RS09730	2097404..2101240	-	3837	WP_080704461.1	SIR2 family protein	-
EL288_RS09735	2101450..2102025	-	576	WP_080704460.1	PIN domain-containing protein	Toxin
EL288_RS09740	2102022..2102489	-	468	WP_033459772.1	helix-turn-helix domain-containing protein	Antitoxin
EL288_RS09750	2103142..2103399	+	258	WP_019247974.1	helix-turn-helix domain-containing protein	-
EL288_RS09755	2103401..2104741	+	1341	WP_033459770.1	type II toxin-antitoxin system HipA family toxin	-
EL288_RS09760	2104837..2105526	-	690	WP_033459800.1	TetR/AcrR family transcriptional regulator	-
EL288_RS09765	2105539..2106969	+	1431	WP_080703532.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-114)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21708.79 Da
• Isoelectric Point: 5.6548

>T287686 WP_080704460.1 NZ_LR134326:c2102025-2101450 [Bordetella bronchiseptica]
MRYSPFTVIFDACVLYPAPLRDFLMWLGLSGRVRARWSRDIHKEWKRNLLLNRPDLTRAQVDRTSDLMDRAIPDGLVDGY
EDLIAGLTLPDPDDRHVLATAIRCGASVIVTFNQRDFPADVLASYGVESQHPDEFVENLFDLDAAAVVAAAQRQRAQLKN
PPVDVDHYLEILFRQGLVQTVKNLTTYRSIL

Nucleotide

• Length: 576 bp

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17318.70 Da
• Isoelectric Point: 6.4950

>AT287686 WP_033459772.1 NZ_LR134326:c2102489-2102022 [Bordetella bronchiseptica]
MTTTTPTKMTLPAEREVQAAVQGQRALAAYLATRFETQHIQIFDDRNQAHQVELPTSALRLLVDILAELAGGNAVKVVPV
HAELTTQEAADMLNVSRPHLVKLLEDGVLPFHRTGKHRRVRFADLMQYKDTRDRASEEAMAELARQAQESGMGYE

Nucleotide

• Length: 468 bp