Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 1946069..1946600 Replicon chromosome
Accession NZ_LR134326
Organism Bordetella bronchiseptica strain NCTC10543

Toxin (Protein)


Gene name shpA Uniprot ID A0A0C6P1L1
Locus tag EL288_RS09080 Protein ID WP_015064047.1
Coordinates 1946334..1946600 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID K0MF02
Locus tag EL288_RS09075 Protein ID WP_003816743.1
Coordinates 1946069..1946347 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL288_RS09050 1941499..1942593 + 1095 WP_003812637.1 TRAP transporter substrate-binding protein -
EL288_RS09055 1942805..1943434 + 630 WP_033451894.1 TRAP transporter small permease subunit -
EL288_RS09060 1943437..1945104 + 1668 WP_003812634.1 TRAP transporter large permease subunit -
EL288_RS09065 1945119..1945775 + 657 WP_003812630.1 phosphoribosylanthranilate isomerase -
EL288_RS09075 1946069..1946347 - 279 WP_003816743.1 BrnA antitoxin family protein Antitoxin
EL288_RS09080 1946334..1946600 - 267 WP_015064047.1 BrnT family toxin Toxin
EL288_RS09085 1946831..1948372 - 1542 WP_003812624.1 M81 family metallopeptidase -
EL288_RS09090 1948434..1949312 - 879 WP_003812621.1 tripartite tricarboxylate transporter substrate binding protein -
EL288_RS09095 1949709..1950341 + 633 WP_003812619.1 PAS domain-containing protein -
EL288_RS09100 1950452..1951162 + 711 WP_003812617.1 aquaporin Z -
EL288_RS09105 1951201..1951473 - 273 WP_003812615.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(12-86)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10090.52 Da        Isoelectric Point: 9.4798

>T287685 WP_015064047.1 NZ_LR134326:c1946600-1946334 [Bordetella bronchiseptica]
MDITYDPAKNDKNIADRGLSFELVRGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Download         Length: 267 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10412.89 Da        Isoelectric Point: 10.5548

>AT287685 WP_003816743.1 NZ_LR134326:c1946347-1946069 [Bordetella bronchiseptica]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C6P1L1

Antitoxin

Source ID Structure
AlphaFold DB K0MF02

References