Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1745236..1745848 Replicon chromosome
Accession NZ_LR134323
Organism Streptococcus urinalis strain NCTC13766

Toxin (Protein)


Gene name parE Uniprot ID G5KDE2
Locus tag EL133_RS08955 Protein ID WP_006739169.1
Coordinates 1745513..1745848 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID G5KDE1
Locus tag EL133_RS08950 Protein ID WP_006738697.1
Coordinates 1745236..1745523 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL133_RS08925 1740525..1741505 - 981 WP_006739323.1 C-terminal binding protein -
EL133_RS08930 1741516..1741956 - 441 WP_006739919.1 hypothetical protein -
EL133_RS08935 1741953..1743311 - 1359 WP_006739787.1 PTS transporter subunit EIIC -
EL133_RS08940 1743646..1744488 - 843 WP_006740372.1 MurR/RpiR family transcriptional regulator -
EL133_RS08945 1744942..1745025 - 84 Protein_1759 30S ribosomal protein S9 -
EL133_RS08950 1745236..1745523 + 288 WP_006738697.1 hypothetical protein Antitoxin
EL133_RS08955 1745513..1745848 + 336 WP_006739169.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EL133_RS08960 1746153..1746623 - 471 WP_006739650.1 hypothetical protein -
EL133_RS08965 1746791..1748047 - 1257 Protein_1763 plasmid recombination protein -
EL133_RS08970 1748364..1748798 - 435 WP_006739931.1 hypothetical protein -
EL133_RS08975 1748834..1748941 - 108 Protein_1765 replication initiation protein -
EL133_RS08990 1749271..1749599 - 329 Protein_1766 hypothetical protein -
EL133_RS09000 1749810..1750148 - 339 WP_006739797.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
EL133_RS09005 1750160..1750786 - 627 WP_196792586.1 CadD family cadmium resistance transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13296.00 Da        Isoelectric Point: 4.7846

>T287683 WP_006739169.1 NZ_LR134323:1745513-1745848 [Streptococcus urinalis]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIINDIEKLEVFPEVGFDADEKYGSEISNYHSTRGYTLSKN
YIVLYHIEEEENRVVIDYLLPTRSDYMKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10878.45 Da        Isoelectric Point: 4.7271

>AT287683 WP_006738697.1 NZ_LR134323:1745236-1745523 [Streptococcus urinalis]
MVTAEKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEISKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G5KDE2

Antitoxin

Source ID Structure
AlphaFold DB G5KDE1

References