Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1458431..1458988 Replicon chromosome
Accession NZ_LR134323
Organism Streptococcus urinalis strain NCTC13766

Toxin (Protein)


Gene name relE Uniprot ID G5KI09
Locus tag EL133_RS07470 Protein ID WP_003047235.1
Coordinates 1458716..1458988 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G5KI08
Locus tag EL133_RS07465 Protein ID WP_001140275.1
Coordinates 1458431..1458712 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL133_RS07435 1453784..1454233 - 450 WP_003047243.1 DUF4314 domain-containing protein -
EL133_RS07440 1454235..1454486 - 252 WP_003047241.1 hypothetical protein -
EL133_RS07445 1454661..1455839 - 1179 WP_003047239.1 DNA (cytosine-5-)-methyltransferase -
EL133_RS07450 1455836..1456426 - 591 WP_000073292.1 HNH endonuclease -
EL133_RS07455 1456426..1457679 - 1254 WP_006740451.1 DNA modification methylase -
EL133_RS07460 1457651..1458106 - 456 WP_000999415.1 hypothetical protein -
EL133_RS07465 1458431..1458712 + 282 WP_001140275.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
EL133_RS07470 1458716..1458988 + 273 WP_003047235.1 type II toxin-antitoxin system YafQ family toxin Toxin
EL133_RS07475 1459031..1459390 - 360 WP_001138026.1 HNH endonuclease -
EL133_RS07480 1459392..1460132 - 741 WP_003047233.1 methionine adenosyltransferase domain-containing protein -
EL133_RS07485 1460536..1461033 - 498 WP_006738435.1 hypothetical protein -
EL133_RS07490 1461026..1462402 - 1377 WP_000773770.1 DEAD/DEAH box helicase -
EL133_RS07495 1462383..1462664 - 282 WP_001208489.1 VRR-NUC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1430820..1469616 38796


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-90)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10433.06 Da        Isoelectric Point: 8.9949

>T287682 WP_003047235.1 NZ_LR134323:1458716-1458988 [Streptococcus urinalis]
MLQLVTTNQFRKDVKRAKKRGLNLKKLEAVLDPLQKEETLDEKHRDHALVGNYMGFRECHIEPDWLLVYAIDKGQLILTA
SRTGSHSDLF

Download         Length: 273 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10323.68 Da        Isoelectric Point: 4.4155

>AT287682 WP_001140275.1 NZ_LR134323:1458431-1458712 [Streptococcus urinalis]
MAKTANINLRIEPSTKAQAESLFGSFGISVTDAINIFLNTSIMEGGFPFQIKQPRYNRETELAMEEARQIMEGKVTTKSY
ASVSDLMADLNED

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829ID91

References