Detailed information of TA system TA287681

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1391381..1392804
• Replicon: chromosome
• Accession: NZ_LR134323
• Organism: Streptococcus urinalis strain NCTC13766

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: G5KHT1
• Locus tag: EL133_RS07095
• Protein ID: WP_006738822.1
• Coordinates: 1391968..1392804 (+)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: G5KHT0
• Locus tag: EL133_RS07090
• Protein ID: WP_006740461.1
• Coordinates: 1391381..1391971 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL133_RS07075	1389967..1390247	-	281	Protein_1395	hypothetical protein	-
EL133_RS07080	1390240..1390602	-	363	WP_006740608.1	hypothetical protein	-
EL133_RS11390	1390599..1390769	-	171	WP_006738681.1	hypothetical protein	-
EL133_RS07085	1390763..1391269	+	507	Protein_1398	CHAP domain-containing protein	-
EL133_RS07090	1391381..1391971	+	591	WP_006740461.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
EL133_RS07095	1391968..1392804	+	837	WP_006738822.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EL133_RS07100	1392989..1393186	+	198	WP_006738512.1	helix-turn-helix domain-containing protein	-
EL133_RS07105	1393251..1394501	+	1251	WP_006738960.1	site-specific integrase	-
EL133_RS07110	1394675..1395397	-	723	WP_006738458.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
EL133_RS07115	1395491..1396653	-	1163	Protein_1404	exo-alpha-sialidase	-
EL133_RS07120	1396667..1397113	-	447	WP_006740228.1	YhcH/YjgK/YiaL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31894.27 Da
• Isoelectric Point: 5.0087

>T287681 WP_006738822.1 NZ_LR134323:1391968-1392804 [Streptococcus urinalis]
VNKAKLTALCHKVSKETGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVHQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDVYILSKLKISDIDSQQLLTACQRTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23177.56 Da
• Isoelectric Point: 8.3205

>AT287681 WP_006740461.1 NZ_LR134323:1391381-1391971 [Streptococcus urinalis]
MSNKETVLNYLKQNNGIITYKDCKELGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGFTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVPKEIVDLGVISVKTPWGQTVKTYDFERIICDFIQNRKKIDNELFVKT
LKAYVNYPNKNLTNLYQYAEKMKIINQIKQTLEVLM

Nucleotide

• Length: 591 bp

Structures

Toxin

• AlphaFold DB: G5KHT1

Antitoxin

• AlphaFold DB: G5KHT0