Detailed information of TA system TA287680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1073209..1074449
• Replicon: chromosome
• Accession: NZ_LR134323
• Organism: Streptococcus urinalis strain NCTC13766

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: G5KG26
• Locus tag: EL133_RS05550
• Protein ID: WP_006740290.1
• Coordinates: 1073209..1073973 (-)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: EL133_RS05555
• Protein ID: WP_006738614.1
• Coordinates: 1073973..1074449 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL133_RS05530	1069127..1069492	-	366	WP_003050778.1	MobC family plasmid mobilization relaxosome protein	-
EL133_RS05535	1069502..1069861	-	360	WP_003050781.1	hypothetical protein	-
EL133_RS05540	1070195..1071880	-	1686	WP_006739047.1	ATP-binding protein	-
EL133_RS05545	1071873..1073159	-	1287	WP_006739494.1	SIR2 family protein	-
EL133_RS05550	1073209..1073973	-	765	WP_006740290.1	zeta toxin family protein	Toxin
EL133_RS05555	1073973..1074449	-	477	WP_006738614.1	helix-turn-helix domain-containing protein	Antitoxin
EL133_RS05560	1074521..1074808	-	288	WP_006738783.1	hypothetical protein	-
EL133_RS05565	1074852..1075247	-	396	WP_006739198.1	hypothetical protein	-
EL133_RS05570	1075251..1075478	-	228	WP_006740484.1	hypothetical protein	-
EL133_RS05575	1075532..1076620	-	1089	WP_006739884.1	toprim domain-containing protein	-
EL133_RS05580	1076660..1077298	-	639	WP_006739854.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (27-213)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29120.17 Da
• Isoelectric Point: 6.8466

>T287680 WP_006740290.1 NZ_LR134323:c1073973-1073209 [Streptococcus urinalis]
MRLEEFSKDDFDLALKRPLRSLTRGKTTSVNPKAILIGGQSGVGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLALQD
EYGKNSVDYTKGFARKMVEHLVDELSKQGYHLLIEGTLRTTEVPRKTARLLKSRGYQVSLALIATKPELSYLSTLIRYEE
VYAVNPSQARATPKEHHDGIVEHLLDNLRELETDKLFEQIQIYQRDRTCVYDSGMDEGSAADVLQECLFGKWSTVEEEML
KVGQERLREMQELK

Nucleotide

• Length: 765 bp

>T287680 NZ_LR134323:c1073973-1073209 [Streptococcus urinalis]
ATGCGGTTAGAAGAATTTAGCAAAGATGACTTTGACTTAGCCTTAAAACGGCCCCTTCGTTCCTTAACTCGTGGTAAAAC
GACATCAGTTAACCCCAAAGCCATCTTAATTGGTGGGCAAAGCGGAGTGGGTAAGACAACGATACACCGTATCAAGCAGA
AAGAGTTCCAAGGCAATATCATTATTATTGACGGTGACAGCTATCGTTCTTTACACCCGAATTATCTAGCTTTACAAGAT
GAATACGGTAAAAATAGCGTGGATTATACCAAAGGTTTTGCAAGAAAAATGGTGGAACATCTTGTAGATGAGCTAAGTAA
GCAGGGGTATCATTTGTTAATCGAAGGAACTTTGAGAACGACAGAAGTCCCGCGAAAAACTGCTCGGCTATTGAAATCAC
GAGGCTATCAAGTCTCATTAGCTTTGATAGCAACCAAGCCTGAATTGTCCTATCTCAGCACCTTAATCCGTTATGAAGAA
GTTTATGCAGTTAATCCAAGTCAGGCTAGAGCAACTCCTAAAGAACATCACGATGGTATTGTAGAGCATTTACTTGATAA
CTTACGAGAATTAGAAACTGATAAACTCTTTGAACAGATTCAAATTTATCAGAGGGATAGAACCTGTGTTTATGATTCTG
GAATGGATGAAGGCTCAGCTGCTGATGTCCTACAAGAATGCCTATTTGGAAAATGGAGTACGGTGGAGGAGGAGATGCTT
AAAGTGGGGCAGGAACGGTTGAGGGAGATGCAAGAATTGAAGTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18099.49 Da
• Isoelectric Point: 4.3739

>AT287680 WP_006738614.1 NZ_LR134323:c1074449-1073973 [Streptococcus urinalis]
MIGENIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVTTELIDCICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLSDLINTKIYLVNTFDEVERYNGYLDGIERMLELAHHQVVA

Nucleotide

• Length: 477 bp

>AT287680 NZ_LR134323:c1074449-1073973 [Streptococcus urinalis]
ATGATTGGAGAGAATATCAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
ACGAAATAGCCTTAGCCGTTATGAAAATGGTACGAGTTCAGTCACAACAGAACTTATAGACTGCATTTGTCAGAAATTCA
ATGTTTCTTATGTTGATATTGTAGGAGAAGAGAAGATGTTAACACCAGTAGAAGATTATCAATTGACGCTAAAAATAGAA
GTCATCAAAGAGCGTGGCGCAGCGATTTTATCTCAACTATATCGCTATCAAGATAGTCAAGGAATCGCTTTTGACGATGA
GACCAATCCTTGGATTTTAATGAGTGATGACTTGTCAGACCTTATCAATACCAAGATTTACCTTGTTAATACGTTTGATG
AAGTGGAGCGTTACAATGGTTATTTGGATGGTATTGAGCGCATGTTGGAGCTTGCTCATCATCAGGTGGTGGCTTAA

Structures

Toxin

• AlphaFold DB: G5KG26