Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2502718..2503280 Replicon chromosome
Accession NZ_LR134322
Organism Lacticaseibacillus rhamnosus strain NCTC13710

Toxin (Protein)


Gene name mazF Uniprot ID C2JYM4
Locus tag EL156_RS12560 Protein ID WP_005692155.1
Coordinates 2502718..2503065 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EL156_RS12565 Protein ID WP_014571589.1
Coordinates 2503065..2503280 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL156_RS12525 2498213..2499454 - 1242 WP_005692160.1 acyltransferase -
EL156_RS12530 2499451..2500152 - 702 WP_005692159.1 ABC transporter ATP-binding protein -
EL156_RS12535 2500145..2500963 - 819 WP_014571588.1 ABC transporter permease subunit -
EL156_RS12540 2501204..2501872 - 669 WP_005692157.1 tRNA ligase -
EL156_RS12550 2502052..2502195 + 144 WP_020752296.1 hypothetical protein -
EL156_RS12560 2502718..2503065 - 348 WP_005692155.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL156_RS12565 2503065..2503280 - 216 WP_014571589.1 hypothetical protein Antitoxin
EL156_RS12570 2503377..2505212 - 1836 WP_015764721.1 ABC transporter ATP-binding protein/permease -
EL156_RS12575 2505199..2506989 - 1791 WP_015764722.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13150.01 Da        Isoelectric Point: 7.9817

>T287677 WP_005692155.1 NZ_LR134322:c2503065-2502718 [Lacticaseibacillus rhamnosus]
MTYKAKQGDVVWLDFDPSEGHEIRKRCPAVVLSSNAYNRATGFVIVAPITSTIRTLPGYVDIVSNKIRGQVVTSQVYSLD
VTEQGNRKIDFIERMNIEDFYTVAQFTKMNFDFKF

Download         Length: 348 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7986.13 Da        Isoelectric Point: 5.7995

>AT287677 WP_014571589.1 NZ_LR134322:c2503280-2503065 [Lacticaseibacillus rhamnosus]
MDVKVVKRGNSLALSLPSSAGFKRGEAFLLISDEKGGYLLIPKVKNPYTKAKPLSFHQEEAWPDFDYEDIE

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9DS75

Antitoxin

Source ID Structure

References