Detailed information of TA system TA287673

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2548149..2548648
• Replicon: chromosome
• Accession: NZ_LR134321
• Organism: Shewanella baltica strain NCTC10737

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: EL185_RS11030
• Protein ID: WP_197721134.1
• Coordinates: 2548149..2548319 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: EL185_RS11035
• Protein ID: WP_126491952.1
• Coordinates: 2548316..2548648 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL185_RS11015	2545088..2545693	+	606	WP_006086154.1	DUF998 domain-containing protein	-
EL185_RS11020	2545849..2546532	+	684	WP_126491951.1	hypothetical protein	-
EL185_RS11025	2546624..2547723	-	1100	Protein_2101	group II intron reverse transcriptase/maturase	-
EL185_RS11030	2548149..2548319	+	171	WP_197721134.1	type II toxin-antitoxin system HicA family toxin	Toxin
EL185_RS11035	2548316..2548648	+	333	WP_126491952.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
EL185_RS11040	2549219..2549647	-	429	WP_126491953.1	hypothetical protein	-
EL185_RS11045	2549805..2550375	+	571	Protein_2105	transposase	-
EL185_RS11050	2550713..2551201	+	489	WP_126491954.1	hypothetical protein	-
EL185_RS11055	2551390..2552343	+	954	WP_126491955.1	hypothetical protein	-
EL185_RS11060	2552330..2553319	+	990	WP_126491956.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (2-47)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6418.34 Da
• Isoelectric Point: 8.8787

>T287673 WP_197721134.1 NZ_LR134321:2548149-2548319 [Shewanella baltica]
MFKALGADVSERAGSRVAVVLFDEVRVFHRPHPSPNTDKRAITSIWKWLEENEVKP

Nucleotide

• Length: 171 bp

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12343.08 Da
• Isoelectric Point: 8.9218

>AT287673 WP_126491952.1 NZ_LR134321:2548316-2548648 [Shewanella baltica]
MNIMVVDGYKAKIEYDPQLDQFRGEILGLNGSADFYGTNPASLRREFKNSLKVFLEVCKEKGIKPSKEFSGKFNLRIPPH
LHAEVAARASAEGKSINQWVSEVLRNSVSE

Nucleotide

• Length: 333 bp