Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1648697..1649283 Replicon chromosome
Accession NZ_LR134320
Organism Streptococcus mutans strain NCTC10832

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL130_RS08325 Protein ID WP_002265423.1
Coordinates 1649092..1649283 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H5AQZ7
Locus tag EL130_RS08320 Protein ID WP_002269450.1
Coordinates 1648697..1649074 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL130_RS08310 1645479..1645763 - 285 WP_002278032.1 helix-turn-helix transcriptional regulator -
EL130_RS08315 1646079..1646972 + 894 WP_002272311.1 LexA family transcriptional regulator IrvR -
EL130_RS08320 1648697..1649074 - 378 WP_002269450.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL130_RS08325 1649092..1649283 - 192 WP_002265423.1 type II toxin-antitoxin system HicA family toxin Toxin
EL130_RS08330 1649380..1650042 - 663 WP_002263546.1 type II-A CRISPR-associated protein Csn2 -
EL130_RS08335 1650032..1650376 - 345 WP_002264918.1 CRISPR-associated endonuclease Cas2 -
EL130_RS08340 1650373..1651239 - 867 WP_002264919.1 type II CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7177.52 Da        Isoelectric Point: 10.7089

>T287666 WP_002265423.1 NZ_LR134320:c1649283-1649092 [Streptococcus mutans]
MPLTGKELARLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Download         Length: 192 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14293.28 Da        Isoelectric Point: 4.5628

>AT287666 WP_002269450.1 NZ_LR134320:c1649074-1648697 [Streptococcus mutans]
MLKSYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALEKKLQL

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H5AQZ7

References