Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | SmuAT/- |
| Location | 210152..211113 | Replicon | chromosome |
| Accession | NZ_LR134320 | ||
| Organism | Streptococcus mutans strain NCTC10832 | ||
Toxin (Protein)
| Gene name | smuT | Uniprot ID | - |
| Locus tag | EL130_RS01125 | Protein ID | WP_002281462.1 |
| Coordinates | 210598..211113 (-) | Length | 172 a.a. |
Antitoxin (Protein)
| Gene name | smuA | Uniprot ID | - |
| Locus tag | EL130_RS01120 | Protein ID | WP_002264865.1 |
| Coordinates | 210152..210598 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EL130_RS10140 | 206300..206656 | - | 357 | Protein_195 | transposase family protein | - |
| EL130_RS01085 | 206823..207614 | + | 792 | WP_025985792.1 | DUF4037 domain-containing protein | - |
| EL130_RS01090 | 207812..208144 | - | 333 | WP_002265705.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| EL130_RS01095 | 208138..208383 | - | 246 | WP_002283816.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| EL130_RS01100 | 208705..209097 | - | 393 | WP_002262992.1 | 30S ribosomal protein S9 | - |
| EL130_RS01105 | 209122..209568 | - | 447 | WP_002262993.1 | 50S ribosomal protein L13 | - |
| EL130_RS01115 | 209961..210155 | - | 195 | WP_002262994.1 | helix-turn-helix transcriptional regulator | - |
| EL130_RS01120 | 210152..210598 | - | 447 | WP_002264865.1 | hypothetical protein | Antitoxin |
| EL130_RS01125 | 210598..211113 | - | 516 | WP_002281462.1 | hypothetical protein | Toxin |
| EL130_RS01130 | 211245..212105 | - | 861 | WP_002283815.1 | DegV family protein | - |
| EL130_RS01135 | 212129..212875 | - | 747 | WP_002283814.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| EL130_RS01140 | 213191..213745 | + | 555 | WP_002262999.1 | PadR family transcriptional regulator | - |
| EL130_RS01145 | 213934..214926 | + | 993 | WP_002269856.1 | BtrH N-terminal domain-containing protein | - |
| EL130_RS01150 | 214962..215699 | - | 738 | WP_002273490.1 | MerR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 206528..206656 | 128 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19590.23 Da Isoelectric Point: 9.8779
>T287665 WP_002281462.1 NZ_LR134320:c211113-210598 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCHSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCHSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
Download Length: 516 bp
Antitoxin
Download Length: 149 a.a. Molecular weight: 16996.29 Da Isoelectric Point: 9.5767
>AT287665 WP_002264865.1 NZ_LR134320:c210598-210152 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESIIKCSYLGLSGFWLICMGASVVYRHYLDKKEADK
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESIIKCSYLGLSGFWLICMGASVVYRHYLDKKEADK
Download Length: 447 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|