287664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 207812..208383 Replicon chromosome
Accession NZ_LR134320
Organism Streptococcus mutans strain NCTC10832

Toxin (Protein)


Gene name mazF Uniprot ID A0A2J9QC66
Locus tag EL130_RS01090 Protein ID WP_002265705.1
Coordinates 207812..208144 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag EL130_RS01095 Protein ID WP_002283816.1
Coordinates 208138..208383 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL130_RS01065 203331..203933 - 603 WP_002274543.1 NAD(P)H-dependent oxidoreductase -
EL130_RS01070 204075..204923 - 849 WP_002267691.1 alpha/beta hydrolase -
EL130_RS01075 204901..206121 - 1221 WP_002270688.1 PTS sugar transporter subunit IIC -
EL130_RS10140 206300..206656 - 357 Protein_195 transposase family protein -
EL130_RS01085 206823..207614 + 792 WP_025985792.1 DUF4037 domain-containing protein -
EL130_RS01090 207812..208144 - 333 WP_002265705.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
EL130_RS01095 208138..208383 - 246 WP_002283816.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EL130_RS01100 208705..209097 - 393 WP_002262992.1 30S ribosomal protein S9 -
EL130_RS01105 209122..209568 - 447 WP_002262993.1 50S ribosomal protein L13 -
EL130_RS01115 209961..210155 - 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
EL130_RS01120 210152..210598 - 447 WP_002264865.1 hypothetical protein -
EL130_RS01125 210598..211113 - 516 WP_002281462.1 hypothetical protein -
EL130_RS01130 211245..212105 - 861 WP_002283815.1 DegV family protein -
EL130_RS01135 212129..212875 - 747 WP_002283814.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 206528..206656 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12664.56 Da        Isoelectric Point: 6.4634

>T287664 WP_002265705.1 NZ_LR134320:c208144-207812 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9269.58 Da        Isoelectric Point: 4.3021

>AT287664 WP_002283816.1 NZ_LR134320:c208383-208138 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNIPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QC66

Antitoxin

Source ID Structure

References