Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1722897..1723513 Replicon chromosome
Accession NZ_LR134318
Organism Pseudomonas fluorescens strain NCTC9428

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag EL257_RS07910 Protein ID WP_126361315.1
Coordinates 1722897..1723109 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag EL257_RS07915 Protein ID WP_126361317.1
Coordinates 1723109..1723513 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL257_RS07885 1718013..1720001 + 1989 WP_126361307.1 heme lyase CcmF/NrfE family subunit -
EL257_RS07890 1719998..1720534 + 537 WP_126361309.1 DsbE family thiol:disulfide interchange protein -
EL257_RS07895 1720531..1721001 + 471 WP_126361311.1 cytochrome c-type biogenesis protein CcmH -
EL257_RS07900 1720998..1722200 + 1203 WP_126361313.1 c-type cytochrome biogenesis protein CcmI -
EL257_RS07905 1722226..1722630 + 405 WP_073472737.1 hypothetical protein -
EL257_RS07910 1722897..1723109 + 213 WP_126361315.1 type II toxin-antitoxin system HicA family toxin Toxin
EL257_RS07915 1723109..1723513 + 405 WP_126361317.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EL257_RS07920 1723585..1724784 - 1200 WP_126361319.1 MFS transporter -
EL257_RS07925 1724951..1725949 - 999 WP_126361321.1 sulfate ABC transporter substrate-binding protein -
EL257_RS07930 1726197..1727021 - 825 WP_126361323.1 ion transporter -
EL257_RS07935 1727043..1727957 - 915 WP_126361326.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7878.05 Da        Isoelectric Point: 10.7251

>T287660 WP_126361315.1 NZ_LR134318:1722897-1723109 [Pseudomonas fluorescens]
VQSRLLIKELEAAGWTLDRVTGSHHIFKHRYNPHTIPVPHPKKDLPLGTVKSIRRRAGLHNPPAGYEGDP

Download         Length: 213 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14832.78 Da        Isoelectric Point: 4.2870

>AT287660 WP_126361317.1 NZ_LR134318:1723109-1723513 [Pseudomonas fluorescens]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEDAYNAAVEIAHIMLQEIAADGESIPMPTSASAHRNNLEFADMGWGM
LDLDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References