Detailed information of TA system TA287657

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 2200781..2202204
• Replicon: chromosome
• Accession: NZ_LR134316
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain NCTC6181

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: EL139_RS10795
• Protein ID: WP_111715775.1
• Coordinates: 2201368..2202204 (+)
• Length: 279 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: EL139_RS10790
• Protein ID: WP_111715777.1
• Coordinates: 2200781..2201371 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EL139_RS10775	2197413..2199323	+	1911	WP_111715782.1	conjugal transfer protein	-
EL139_RS10780	2199310..2199537	+	228	WP_101750352.1	hypothetical protein	-
EL139_RS10785	2199556..2200668	+	1113	WP_111715780.1	CHAP domain-containing protein	-
EL139_RS10790	2200781..2201371	+	591	WP_111715777.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
EL139_RS10795	2201368..2202204	+	837	WP_111715775.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
EL139_RS10800	2202389..2202586	+	198	WP_006738512.1	helix-turn-helix domain-containing protein	-
EL139_RS10805	2202651..2203901	+	1251	WP_101750348.1	site-specific integrase	-
EL139_RS10810	2204132..2205169	-	1038	WP_111715772.1	ammonium transporter	-
EL139_RS10815	2205273..2206400	+	1128	WP_111715770.1	NAD(P)-binding domain-containing protein	-
EL139_RS11185	2206452..2206592	+	141	WP_003049996.1	hypothetical protein	-
EL139_RS10820	2206695..2206907	-	213	WP_111715768.1	YdbC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	tufA	2120435..2249584	129149

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (7-52)

Sequences

Toxin

Protein

• Length: 279 a.a.
• Molecular weight: 31937.34 Da
• Isoelectric Point: 5.1824

>T287657 WP_111715775.1 NZ_LR134316:2201368-2202204 [Streptococcus dysgalactiae subsp. equisimilis]
VNKAKLTALCHKVSKETGLTFNSVMTYYFLEIILKKLSQSAYAQNYIFKGGFLLSNVVGVASRSTVDIDFLFSKMNLSEE
TVHQQLEDILGKSDEDISFTIQSVTAIKESDDYGGYRASILCQLENIRQVIHLDIATGDIVTPQPITYDYKPIFTSEQFP
IIAYTIETILAEKLQTIYSRSFLNSRSKDFYDIYILSKLKKSEIDSQQLLTACQRTFDYRGTELDFDKFINLLETFKTDS
TQNHQWENYSKKYSYTKGITFNDVLTEMTDLLVTIKNL

Nucleotide

• Length: 837 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23193.56 Da
• Isoelectric Point: 8.3205

>AT287657 WP_111715777.1 NZ_LR134316:2200781-2201371 [Streptococcus dysgalactiae subsp. equisimilis]
MSNKETVLNYLKQNNGIITYKDCKELGVPAVYLSRLENEEKIFRVDKGIYLSTDGDYDEYYFFQYRFSRAIYSYVSALYL
QGFTDEIPQYFEVTVPRGYRFNNPPQNLAVHTVPKEIVDLGIISIKTPWGQTVKTYDFERIICDFIQNRKKIDNELFVKT
LKAYVNYPNKNLTNLYQYAEKMKIINQTKQTLEVLM

Nucleotide

• Length: 591 bp