Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3900174..3900750 Replicon chromosome
Accession NZ_LR134315
Organism Escherichia coli strain NCTC9064

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag EL184_RS18965 Protein ID WP_001297643.1
Coordinates 3900463..3900750 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag EL184_RS18960 Protein ID WP_072644498.1
Coordinates 3900174..3900476 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EL184_RS18945 3896770..3898920 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
EL184_RS18950 3898970..3899173 + 204 WP_000467859.1 YbdD/YjiX family protein -
EL184_RS18955 3899184..3900140 + 957 WP_001393094.1 GTPase -
EL184_RS18960 3900174..3900476 - 303 WP_072644498.1 BrnA antitoxin family protein Antitoxin
EL184_RS18965 3900463..3900750 - 288 WP_001297643.1 BrnT family toxin Toxin
EL184_RS18970 3900949..3901646 - 698 Protein_3673 IS1 family transposase -
EL184_RS18975 3902018..3903205 + 1188 WP_096835591.1 multidrug efflux MFS transporter MdtM -
EL184_RS18980 3903246..3904526 + 1281 WP_096835590.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3900949..3901242 293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T287653 WP_001297643.1 NZ_LR134315:c3900750-3900463 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11511.95 Da        Isoelectric Point: 9.4646

>AT287653 WP_072644498.1 NZ_LR134315:c3900476-3900174 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDISPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure

References