28765

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2808697..2809349 Replicon chromosome
Accession NC_020089
Organism Mycobacterium tuberculosis 7199-99

Toxin (Protein)


Gene name vapC Uniprot ID Q7D717
Locus tag MT7199_RS13095 Protein ID WP_003900860.1
Coordinates 2808924..2809349 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ24
Locus tag MT7199_RS13090 Protein ID WP_003412749.1
Coordinates 2808697..2808918 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MT7199_RS13075 2806937..2807143 - 207 WP_003899347.1 hypothetical protein -
MT7199_RS13080 2807279..2807902 + 624 WP_003900858.1 TIGR00725 family protein -
MT7199_RS13085 2807892..2808644 + 753 WP_003900859.1 hypothetical protein -
MT7199_RS13090 2808697..2808918 + 222 WP_003412749.1 antitoxin Antitoxin
MT7199_RS13095 2808924..2809349 + 426 WP_003900860.1 type II toxin-antitoxin system VapC family toxin Toxin
MT7199_RS13100 2809372..2810553 - 1182 WP_003899351.1 2-oxo acid dehydrogenase subunit E2 -
MT7199_RS13105 2810550..2811596 - 1047 WP_003412757.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
MT7199_RS13110 2811607..2812710 - 1104 WP_003412761.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
MT7199_RS13115 2812969..2813790 - 822 WP_003412766.1 citrate (pro-3S)-lyase subunit beta -
MT7199_RS13120 2813787..2814344 - 558 WP_003412768.1 MaoC family dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-139)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15333.82 Da        Isoelectric Point: 8.1220

>T28765 WP_003900860.1 NC_020089:2808924-2809349 [Mycobacterium tuberculosis 7199-99]
VALLDVNALVALAWDSHIHHARIREWFTANATLGWATCPLTEAGFVRVSTNPKVLPSAIGIADARPVLVALRAVGGHRFL
ADDVSLVDDDVPLIVGYRQVTDAHLLTLARRRGVRLVTFDAGVFTLAQQRPKTPVELLTIL

Download         Length: 426 bp

>T28765 NC_020089:2808924-2809349 [Mycobacterium tuberculosis 7199-99]
GTGGCGCTGCTCGACGTCAACGCATTGGTCGCGCTGGCGTGGGACTCACACATCCACCACGCCCGGATCCGCGAGTGGTT
TACCGCCAACGCCACGCTCGGCTGGGCGACTTGCCCGCTCACCGAAGCCGGCTTCGTGCGGGTGTCGACGAACCCAAAAG
TACTTCCCAGCGCGATCGGGATCGCAGACGCTCGACCGGTCCTCGTGGCACTACGCGCCGTGGGAGGCCACCGCTTCCTG
GCTGACGACGTATCGCTCGTCGATGACGATGTTCCGTTGATCGTCGGTTATCGCCAGGTGACCGACGCCCATCTGCTGAC
ACTCGCCCGCCGGCGCGGCGTCCGCCTGGTCACCTTCGACGCCGGTGTCTTCACCCTCGCCCAACAACGCCCCAAGACGC
CAGTGGAGCTGCTGACCATCCTCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7864.93 Da        Isoelectric Point: 4.5258

>AT28765 WP_003412749.1 NC_020089:2808697-2808918 [Mycobacterium tuberculosis 7199-99]
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED

Download         Length: 222 bp

>AT28765 NC_020089:2808697-2808918 [Mycobacterium tuberculosis 7199-99]
GTGCGAACGACACTTGACCTTGACGACGATGTGATCGCCGCGGCACGTGAACTTGCCTCCAGCCAGCGCCGCTCGCTCGG
CTCGGTGATTTCCGAACTCGCACGCCGTGGTCTCATGCCCGGACGCGTCGAGGCTGACGACGGGCTGCCGGTGATCCGCG
TTCCAGCCGGGACCCCGCCGATCACACCGGAGATGGTCCGTCGCGCGCTCGATGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7ZFR7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW03

References